Structure of PDB 2npa Chain C Binding Site BS01

Receptor Information

>2npa Chain C (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ETADLKSLAKRIYEAYLKNFNMNKVKARVILSGAASNNPPFVIHDMETLC
MAEKTLVAKLVIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD
LNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPF
CDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQ
EGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTE
SDAALHPLLQEIYRDMY

Ligand information

>2npa Chain D (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ERHKILHRLL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2npa Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists
Resolution	2.3 Å
Binding residue (original residue number in PDB)	K292 N303 Q305 V306 L309 K310 P458 E462
Binding residue (residue number reindexed from 1)	K91 N102 Q104 V105 L108 K109 P257 E261

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:2npa, PDBe:2npa, PDBj:2npa
PDBsum	2npa
PubMed	17157019
UniProt	Q07869\|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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