Structure of PDB 2i82 Chain C Binding Site BS01

Receptor Information
>2i82 Chain C (length=215) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY
PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHP
SPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVL
KPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITH
PAYGNSMTFKAPADF
Ligand information
>2i82 Chain G (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaggggauugaaaauccccuc
<<<<<<.........>>>>>>
Receptor-Ligand Complex Structure
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PDB2i82 Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure
Resolution2.05 Å
Binding residue
(original residue number in PDB)		P636 G637 R638 H642 H661 R662 D664 M665 K677 E680 K684 F687 R688 K694 W719 R722 P723 K733 G759 R760 S761 H762 F780
Binding residue
(residue number reindexed from 1)		P32 G33 R34 H38 H57 R58 D60 M61 K73 E76 K80 F83 R84 K90 W115 R118 P119 K129 G155 R156 S157 H158 F176
Enzymatic activity
Enzyme Commision number 5.4.99.28: tRNA pseudouridine(32) synthase.
5.4.99.29: 23S rRNA pseudouridine(746) synthase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0009982 pseudouridine synthase activity
GO:0016853 isomerase activity
GO:0106029 tRNA pseudouridine synthase activity
GO:0120159 rRNA pseudouridine synthase activity
GO:0140098 catalytic activity, acting on RNA
GO:0160142 23S rRNA pseudouridine(746) synthase activity
GO:0160151 tRNA pseudouridine(32) synthase activity
Biological Process
GO:0000455 enzyme-directed rRNA pseudouridine synthesis
GO:0001522 pseudouridine synthesis
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0008033 tRNA processing
GO:0009451 RNA modification
GO:0031118 rRNA pseudouridine synthesis
GO:0031119 tRNA pseudouridine synthesis

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Molecular Function
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Biological Process
External links
PDB RCSB:2i82, PDBe:2i82, PDBj:2i82
PDBsum2i82
PubMed17188032
UniProtP0AA37|RLUA_ECOLI Dual-specificity RNA pseudouridine synthase RluA (Gene Name=rluA)

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