Structure of PDB 2h9m Chain C Binding Site BS01
Receptor Information
>2h9m Chain C (length=304) Species:
9606
(Homo sapiens) [
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VKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE
KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN
YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN
RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYIL
AATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED
NLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW
KSDC
Ligand information
>2h9m Chain D (length=5) Species:
8364
(Xenopus tropicalis) [
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ARTKQ
Receptor-Ligand Complex Structure
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PDB
2h9m
Structural basis for molecular recognition and presentation of histone H3 By WDR5.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
A47 V48 S49 S91 D107 F133 K259 Y260 C261 F263 I305 L321
Binding residue
(residue number reindexed from 1)
A17 V18 S19 S61 D77 F103 K229 Y230 C231 F233 I275 L291
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0005515
protein binding
GO:0035064
methylated histone binding
GO:0042393
histone binding
GO:0042800
histone H3K4 methyltransferase activity
Biological Process
GO:0000122
negative regulation of transcription by RNA polymerase II
GO:0001501
skeletal system development
GO:0006094
gluconeogenesis
GO:0006325
chromatin organization
GO:0006355
regulation of DNA-templated transcription
GO:0006357
regulation of transcription by RNA polymerase II
GO:0045722
positive regulation of gluconeogenesis
GO:0045815
transcription initiation-coupled chromatin remodeling
GO:0045893
positive regulation of DNA-templated transcription
GO:0045995
regulation of embryonic development
GO:0051302
regulation of cell division
GO:0051726
regulation of cell cycle
GO:0090043
regulation of tubulin deacetylation
Cellular Component
GO:0000123
histone acetyltransferase complex
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0035097
histone methyltransferase complex
GO:0044545
NSL complex
GO:0044665
MLL1/2 complex
GO:0044666
MLL3/4 complex
GO:0048188
Set1C/COMPASS complex
GO:0071339
MLL1 complex
GO:0072686
mitotic spindle
GO:0140672
ATAC complex
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:2h9m
,
PDBe:2h9m
,
PDBj:2h9m
PDBsum
2h9m
PubMed
16946699
UniProt
P61964
|WDR5_HUMAN WD repeat-containing protein 5 (Gene Name=WDR5)
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