Structure of PDB 2h42 Chain C Binding Site BS01

Receptor Information

>2h42 Chain C (length=317) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNL
VQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKI
QNKLTDLEILALLIAALSHDLDHRGVNNSYIQRCHSIMEHHHFDQCLMIL
NSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQ
FNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRE
RKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLL
DGCRKNRQKWQALAEQQ

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2h42 Chain C Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2h42 Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
Resolution	2.3 Å
Binding residue (original residue number in PDB)	H617 H653 D654 D764
Binding residue (residue number reindexed from 1)	H83 H119 D120 D221
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.

Gene Ontology

	Molecular Function
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081	phosphoric diester hydrolase activity

	Biological Process
GO:0007165	signal transduction

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Molecular Function

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Biological Process

External links

PDB	RCSB:2h42, PDBe:2h42, PDBj:2h42
PDBsum	2h42
PubMed	16735511
UniProt	O76074\|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

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