Structure of PDB 2fv2 Chain C Binding Site BS01

Receptor Information
>2fv2 Chain C (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALL
QEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPL
FLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLC
LRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMV
LQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLK
DDTTTKRWLAQLVKNLQE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2fv2 Chain A Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2fv2 Atomic model of human Rcd-1 reveals an armadillo-like-repeat protein with in vitro nucleic acid binding properties.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Q136 D176
Binding residue
(residue number reindexed from 1)		Q135 D175
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0019904 protein domain specific binding
GO:0030374 nuclear receptor coactivator activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006402 mRNA catabolic process
GO:0006417 regulation of translation
GO:0007548 sex differentiation
GO:0017148 negative regulation of translation
GO:0019221 cytokine-mediated signaling pathway
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2fv2, PDBe:2fv2, PDBj:2fv2
PDBsum2fv2
PubMed17189474
UniProtQ92600|CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (Gene Name=CNOT9)

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