Structure of PDB 2ffd Chain C Binding Site BS01

Receptor Information

>2ffd Chain C (length=298) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

YEASILTHDSSIRYLQEIYNSNNQKIVNLKEKVAQLEAQCQEPCKDTVQI
HDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQ
KRLDGSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYA
LRVELEDWNGRTSTADYAMFKVGPEADKYRLTYAYFAGGDAGDAFDGFDF
GDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLN
GVYYQGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLT

Ligand information

>2ffd Chain G (length=4) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GPRV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2ffd The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE.
Resolution	2.89 Å
Binding residue (original residue number in PDB)	F295 D301 F322 D330 K338 C339 H340 Y363 D364
Binding residue (residue number reindexed from 1)	F200 D206 F227 D235 K243 C244 H245 Y268 D269

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005102	signaling receptor binding

	Biological Process
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0051258	protein polymerization

	Cellular Component
GO:0005577	fibrinogen complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2ffd, PDBe:2ffd, PDBj:2ffd
PDBsum	2ffd
PubMed	16689770
UniProt	P02679\|FIBG_HUMAN Fibrinogen gamma chain (Gene Name=FGG)

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