Structure of PDB 2f8x Chain C Binding Site BS01

Receptor Information

>2f8x Chain C (length=424) Species: 9606 (Homo sapiens)

RPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVY
LMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCT
AKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSL
KNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHL
LDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALL
DADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMIND
GASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELT
GQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQV
PVTLVRNDGIIYSTSLTFTYTPEP

Ligand information

>2f8x Chain X (length=18)

gttactgtgggaaagaaa

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2f8x Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
• Resolution: 3.25 Å
• Binding residue (original residue number in PDB): K50 R51 F52 K152 R178 S181 T183
• Binding residue (residue number reindexed from 1): K40 R41 F42 K142 R168 S171 T173

Gene Ontology

Molecular Function

• GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
• GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
• GO:0003677 DNA binding
• GO:0003700 DNA-binding transcription factor activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription
• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:2f8x, PDBe:2f8x, PDBj:2f8x
• PDBsum: 2f8x
• PubMed: 16530044
• UniProt: Q06330|SUH_HUMAN Recombining binding protein suppressor of hairless (Gene Name=RBPJ)