Structure of PDB 2eb1 Chain C Binding Site BS01

Receptor Information
>2eb1 Chain C (length=169) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGD
AILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFK
AVSPELFHVIDDFVQFQLEKEDIEVPKAMGDIFESLAGAIYMDSGMSLET
VWQVYYPMMRPLIEKFSAN
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2eb1 Chain C Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2eb1 Homodimeric Structure and Double-stranded RNA Cleavage Activity of the C-terminal RNase III Domain of Human Dicer
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E47 D152 E155
Binding residue
(residue number reindexed from 1)		E46 D131 E134
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004525 ribonuclease III activity
Biological Process
GO:0006396 RNA processing
GO:0030422 siRNA processing
GO:0031054 pre-miRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:2eb1, PDBe:2eb1, PDBj:2eb1
PDBsum2eb1
PubMed17920623
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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