Structure of PDB 2c5b Chain C Binding Site BS01

Receptor Information

>2c5b Chain C (length=291) Species: 29303 (Streptantibioticus cattleyicolor) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RPIIAFMSDLGTTDDSVAQCKGLMYSICPDVTVVDVCHSMTPWDVEEGAR
YIVDLPRFFPEGTVFATTTYPATGTTTRSVAVRIKQAAKGGARGQWAGSG
AGFERAEGSYIYIAPNNGLLTTVLEEHGYLEAYEVTSPKVIPEQPEPTFY
SREMVAIPSAHLAAGFPLSEVGRPLEDHEIVRFNRPAVEQDGEALVGVVS
AIDHPFGNVWTNIHRTDLEKAGIGYGARLRLTLDGVLPFEAPLTPTFADA
GEIGNIAIYLNSRGYLSIARNAASLAYPYHLKEGMSARVEA

Ligand information

Ligand ID

MET

InChI

InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1

InChIKey

FFEARJCKVFRZRR-BYPYZUCNSA-N

SMILES

Software	SMILES
CACTVS 3.341	CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0	CSCCC(C(=O)O)N
CACTVS 3.341	CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0	CSCC[C@@H](C(=O)O)N
ACDLabs 10.04	O=C(O)C(N)CCSC

Formula

C5 H11 N O2 S

Name

METHIONINE

PDB chain

2c5b Chain B Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2c5b Substrate Specificity in Enzymatic Fluorination. The Fluorinase from Streptomyces Cattleya Accepts 2'-Deoxyadenosine Substrates.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	D210 W217 S269 R270
Binding residue (residue number reindexed from 1)	D203 W210 S262 R263
Annotation score	5

Enzymatic activity

Enzyme Commision number

2.5.1.63: adenosyl-fluoride synthase.

Gene Ontology

	Molecular Function
GO:0016740	transferase activity
GO:0033846	adenosyl-fluoride synthase activity

View graph for
Molecular Function

External links

PDB	RCSB:2c5b, PDBe:2c5b, PDBj:2c5b
PDBsum	2c5b
PubMed	16604208
UniProt	Q70GK9\|FLA_STRCT Fluorinase (Gene Name=flA)

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