Structure of PDB 2ac0 Chain C Binding Site BS01

Receptor Information

>2ac0 Chain C (length=195) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLI
RVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGG
MNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLR

Ligand information

>2ac0 Chain G (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cgggcatgcccg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2ac0 Structural Basis of DNA Recognition by p53 Tetramers
Resolution	1.8 Å
Binding residue (original residue number in PDB)	S241 R248 R273 C275 A276 C277 R280
Binding residue (residue number reindexed from 1)	S146 R153 R178 C180 A181 C182 R185
Binding affinity	PDBbind-CN: Kd=25nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:2ac0, PDBe:2ac0, PDBj:2ac0
PDBsum	2ac0
PubMed	16793544
UniProt	P04637\|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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