Structure of PDB 2a4q Chain C Binding Site BS01

Receptor Information

>2a4q Chain C (length=151) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
M

Ligand information

>2a4q Chain D (length=16) Species: 3052230 (Hepacivirus hominis) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GSVVIVGRIVLSGKPA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2a4q Synthesis and Biological Activity of Macrocyclic Inhibitors of Hepatitis C Virus (HCV) NS3 Protease
Resolution	2.45 Å
Binding residue (original residue number in PDB)	V29 G31 E32 V33 I35 V36 S37 R62 T63 I64 W85 P88 G90
Binding residue (residue number reindexed from 1)	V1 G3 E4 V5 I7 V8 S9 R34 T35 I36 W57 P60 G62

Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D81 G137 S139
Catalytic site (residue number reindexed from 1)	H29 D53 G109 S111
Enzyme Commision number	3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0008233	peptidase activity
GO:0008236	serine-type peptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis
GO:0019062	virion attachment to host cell
GO:0019087	transformation of host cell by virus
GO:0046718	symbiont entry into host cell
GO:0097264	self proteolysis

	Cellular Component
GO:0016020	membrane
GO:0033644	host cell membrane
GO:0044423	virion component

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External links

PDB	RCSB:2a4q, PDBe:2a4q, PDBj:2a4q
PDBsum	2a4q
PubMed	16112859
UniProt	Q91RS4

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