Structure of PDB 1zth Chain C Binding Site BS01

Receptor Information

>1zth Chain C (length=241) Species: 2234 (Archaeoglobus fulgidus)

MKDLKKIESYLDKLRIKEKDGEERKIYAEVLDGRTLKTLYKLSAKGYITA
MGGVISTGKEANVFYADGVFDGKPVAMAVKIYRIMDEYLYGDKEKVFIWT
EKEFRNLERAKEAGVSVPQPYTYMKNVLLMEFIGEDELPAPTLVELGREL
KELDVEGIFNDVVENVKRLYQEAELVHADLSEYNIMYIDKVYFIDMGQAV
TLRHPMAESYLERDVRNIIRFFSKYGVKADFEEMLKEVKGE

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 1zth Chain C Residue 906

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1zth Structure and activity of the atypical serine kinase Rio1.
• Resolution: 1.89 Å
• Binding residue (original residue number in PDB): N201 D212
• Binding residue (residue number reindexed from 1): N184 D195
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004674 protein serine/threonine kinase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0044024 histone H2AS1 kinase activity
• GO:0046872 metal ion binding
• GO:0106310 protein serine kinase activity

Biological Process

• GO:0006338 chromatin remodeling
• GO:0006468 protein phosphorylation
• GO:0016310 phosphorylation

External links

• PDB: RCSB:1zth, PDBe:1zth, PDBj:1zth
• PDBsum: 1zth
• PubMed: 16008568
• UniProt: O28471|RIO1_ARCFU RIO-type serine/threonine-protein kinase Rio1 (Gene Name=rio1)