Structure of PDB 1zkk Chain C Binding Site BS01

Receptor Information
>1zkk Chain C (length=160) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFV
VEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNR
LGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKA
SIEAHPWLKH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1zkk Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase
Resolution1.45 Å
Binding residue
(original residue number in PDB)		Y245 E259 Y262 C270 M272 Y273 Y274 Y336 G337 D338 S343 H347 W349
Binding residue
(residue number reindexed from 1)		Y53 E67 Y70 C78 M80 Y81 Y82 Y144 G145 D146 S151 H155 W157
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1zkk, PDBe:1zkk, PDBj:1zkk
PDBsum1zkk
PubMed15933070
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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