Structure of PDB 1xy3 Chain C Binding Site BS01
Receptor Information
>1xy3 Chain C (length=298) Species:
5059
(Aspergillus flavus) [
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SAVKAARYGKDNVRVYKVHKDEKTGVQTVYEMTVCVLLEGEIETSYTKAD
NSVIVATDSIKNTIYITAKQNPVTPPELFGSILGTHFIEKYNHIHAAHVN
IVCHRWTRMDIDGKPHPHSFIRDSEEKRNVQVDVVEGKGIDIKSSLSGLT
VLKSTNSQFWGFLRDEYTTLKETWDRILSTDVDATWQWKNFSGLQEVRSH
VPKFDATWATAREVTLKTFAEDNSASVQATMYKMAEQILARQQLIETVEY
SLPNKHYFEIDLSWHKGLQNTGKNAEVFAPQSDPNGLIKCTVGRSSLK
Ligand information
Ligand ID
GUN
InChI
InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
InChIKey
UYTPUPDQBNUYGX-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
NC1=Nc2[nH]cnc2C(=O)N1
ACDLabs 10.04
O=C1c2ncnc2N=C(N1)N
OpenEye OEToolkits 1.5.0
c1[nH]c2c(n1)C(=O)NC(=N2)N
Formula
C5 H5 N5 O
Name
GUANINE
ChEMBL
CHEMBL219568
DrugBank
DB02377
ZINC
ZINC000000895129
PDB chain
1xy3 Chain C Residue 902 [
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Receptor-Ligand Complex Structure
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PDB
1xy3
Urate oxidase from Aspergillus flavus: new crystal-packing contacts in relation to the content of the active site.
Resolution
3.2 Å
Binding residue
(original residue number in PDB)
F159 R176 V227
Binding residue
(residue number reindexed from 1)
F159 R176 V227
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
K10 T57 R176 Q228 H256
Catalytic site (residue number reindexed from 1)
K10 T57 R176 Q228 H256
Enzyme Commision number
1.7.3.3
: factor independent urate hydroxylase.
Gene Ontology
Molecular Function
GO:0004846
urate oxidase activity
GO:0016491
oxidoreductase activity
Biological Process
GO:0006144
purine nucleobase metabolic process
GO:0006145
purine nucleobase catabolic process
GO:0019628
urate catabolic process
Cellular Component
GO:0005777
peroxisome
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1xy3
,
PDBe:1xy3
,
PDBj:1xy3
PDBsum
1xy3
PubMed
15735331
UniProt
Q00511
|URIC_ASPFL Uricase (Gene Name=uaZ)
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