Structure of PDB 1xd3 Chain C Binding Site BS01

Receptor Information
>1xd3 Chain C (length=227) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVL
LLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHA
IANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAH
EGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLE
DAIEVCKKFMERDPDELRFNAIALSAA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain1xd3 Chain C Residue 2005 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1xd3 Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate
Resolution1.45 Å
Binding residue
(original residue number in PDB)		Q78 D79
Binding residue
(residue number reindexed from 1)		Q75 D76
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) Q89 C95 H169 D184
Catalytic site (residue number reindexed from 1) Q86 C92 H166 D181
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0019784 deNEDDylase activity
GO:0043130 ubiquitin binding
Biological Process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0016579 protein deubiquitination
GO:0030163 protein catabolic process
GO:0043687 post-translational protein modification
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1xd3, PDBe:1xd3, PDBj:1xd3
PDBsum1xd3
PubMed15531586
UniProtP15374|UCHL3_HUMAN Ubiquitin carboxyl-terminal hydrolase isozyme L3 (Gene Name=UCHL3)

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