Structure of PDB 1x8d Chain C Binding Site BS01

Receptor Information
>1x8d Chain C (length=104) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIRKAFVMQVNPDAHEEYQRRHNPIWPELEAVLKSHGAHNYAIYLDKARN
LLFAMVEIESEERWNAVASTDVCQRWWKYMTDVMPANPDNSPVSSELQEV
FYLP
Ligand information
Ligand IDRNS
InChIInChI=1S/C6H12O5/c1-3(8)5(10)6(11)4(9)2-7/h2-6,8-11H,1H3/t3-,4-,5-,6-/m0/s1
InChIKeyPNNNRSAQSRJVSB-BXKVDMCESA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C[C@@H]([C@@H]([C@H]([C@H](C=O)O)O)O)O
ACDLabs 10.04O=CC(O)C(O)C(O)C(O)C
OpenEye OEToolkits 1.5.0CC(C(C(C(C=O)O)O)O)O
CACTVS 3.341C[CH](O)[CH](O)[CH](O)[CH](O)C=O
CACTVS 3.341C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)C=O
FormulaC6 H12 O5
NameL-RHAMNOSE
ChEMBL
DrugBankDB02961
ZINCZINC000002038606
PDB chain1x8d Chain C Residue 1107 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1x8d Structural Insights into the Monosaccharide Specificity of Escherichia coli Rhamnose Mutarotase
Resolution1.8 Å
Binding residue
(original residue number in PDB)		Y18 H22 Y41 W76 W77
Binding residue
(residue number reindexed from 1)		Y18 H22 Y41 W76 W77
Annotation score1
Binding affinityMOAD: Kd=6.16mM
Enzymatic activity
Enzyme Commision number 5.1.3.32: L-rhamnose mutarotase.
Gene Ontology
Molecular Function
GO:0016853 isomerase activity
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0042803 protein homodimerization activity
GO:0062192 L-rhamnose mutarotase activity
Biological Process
GO:0019299 rhamnose metabolic process
GO:0019301 rhamnose catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1x8d, PDBe:1x8d, PDBj:1x8d
PDBsum1x8d
PubMed15876375
UniProtP32156|RHAM_ECOLI L-rhamnose mutarotase (Gene Name=rhaM)

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