Structure of PDB 1x27 Chain C Binding Site BS01
Receptor Information
>1x27 Chain C (length=164) Species:
9606
(Homo sapiens) [
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MNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIP
FNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGS
FSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNA
SDGLCTRLSRPCQT
Ligand information
>1x27 Chain K (length=5) Species:
10116
(Rattus norvegicus) [
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YDYVH
Receptor-Ligand Complex Structure
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PDB
1x27
Molecular basis for regulation of Src by the docking protein p130Cas
Resolution
2.7 Å
Binding residue
(original residue number in PDB)
R134 R154 S156 S164 K179 H180 Y181 K182 S194 G215
Binding residue
(residue number reindexed from 1)
R72 R92 S94 S102 K117 H118 Y119 K120 S132 G153
Enzymatic activity
Enzyme Commision number
2.7.10.2
: non-specific protein-tyrosine kinase.
External links
PDB
RCSB:1x27
,
PDBe:1x27
,
PDBj:1x27
PDBsum
1x27
PubMed
16245368
UniProt
P06239
|LCK_HUMAN Tyrosine-protein kinase Lck (Gene Name=LCK)
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