Structure of PDB 1v9i Chain C Binding Site BS01

Receptor Information
>1v9i Chain C (length=261) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RCSHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLAL
VYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGS
SDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKV
GDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTT
PPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQP
LKNRCVRGFPK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1v9i Chain C Residue 262 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1v9i Crystal Structure Analysis of the site specific mutant (Q253C) of bovine carbonic anhydrase II
Resolution2.95 Å
Binding residue
(original residue number in PDB)		H95 H97 H120
Binding residue
(residue number reindexed from 1)		H95 H97 H120
Annotation score1
Enzymatic activity
Enzyme Commision number 4.2.1.1: carbonic anhydrase.
4.2.1.69: cyanamide hydratase.
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0018820 cyanamide hydratase activity
GO:0046872 metal ion binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0015670 carbon dioxide transport
GO:0038166 angiotensin-activated signaling pathway
GO:0044070 regulation of monoatomic anion transport
GO:0051453 regulation of intracellular pH
GO:2001150 positive regulation of dipeptide transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0045177 apical part of cell

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1v9i, PDBe:1v9i, PDBj:1v9i
PDBsum1v9i
PubMed
UniProtP00921|CAH2_BOVIN Carbonic anhydrase 2 (Gene Name=CA2)

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