Structure of PDB 1uu0 Chain C Binding Site BS01

Receptor Information

>1uu0 Chain C (length=311) Species: 2336 (Thermotoga maritima)

KTYLALNENPFPFPEDLVDEVFRRLNSDALRIYYDSPDEELIEKILSYLD
TDFLSKNNVSVGNGADEIIYVMMLMFDRSVFFPPTYSCYRIFAKAVGAKF
LEVPLTKDLRIPEVNVGEGDVVFIPNPNNPTGHVFEREEIERILKTGAFV
ALDEAYYEFHGESYVDFLKKYENLAVIRTFSKAFSLAAQRVGYVVASEKF
IDAYNRVRLPFNVSYVSQMFAKVALDHREIFEERTKFIVEERERMKSALR
EMGYRITDSRGNFVFVFMEKEEKERLLEHLRTKNVAVRSFREGVRITIGK
REENDMILREL

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 1uu0 Chain C Residue 1333

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1uu0 Structural Studies of the Catalytic Reaction Pathway of a Hyperthermophilic Histidinol-Phosphate Aminotransferase
• Resolution: 2.85 Å
• Binding residue (original residue number in PDB): G84 A85 D86 T199 S201 R210
• Binding residue (residue number reindexed from 1): G64 A65 D66 T179 S181 R190
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.6.1.9: histidinol-phosphate transaminase.

Gene Ontology

Molecular Function

• GO:0004400 histidinol-phosphate transaminase activity
• GO:0008483 transaminase activity
• GO:0016740 transferase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0042803 protein homodimerization activity

Biological Process

• GO:0000105 L-histidine biosynthetic process
• GO:0009058 biosynthetic process

External links

• PDB: RCSB:1uu0, PDBe:1uu0, PDBj:1uu0
• PDBsum: 1uu0
• PubMed: 15007066
• UniProt: Q9X0D0|HIS8_THEMA Histidinol-phosphate aminotransferase (Gene Name=hisC)