Structure of PDB 1rxt Chain C Binding Site BS01

Receptor Information
>1rxt Chain C (length=325) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWH
CGVRGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITR
RVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMT
MQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQE
EVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNTHKSLKAAYS
FYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGD
GNLQYYLYNWKCPSMGAEKVGIVLQ
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain1rxt Chain C Residue 990 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1rxt Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase
Resolution3.0 Å
Binding residue
(original residue number in PDB)		L276 F298 F326 Y352
Binding residue
(residue number reindexed from 1)		L184 F206 F228 Y252
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N169 F170 L171 T205 Q455
Catalytic site (residue number reindexed from 1) N77 F78 L79 T113 Q325
Enzyme Commision number 2.3.1.-
2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0018030 peptidyl-lysine N6-myristoyltransferase activity
GO:0019107 myristoyltransferase activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006499 N-terminal protein myristoylation
GO:0018008 N-terminal peptidyl-glycine N-myristoylation
GO:0022400 regulation of opsin-mediated signaling pathway
GO:0042180 cellular ketone metabolic process
GO:0072657 protein localization to membrane
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1rxt, PDBe:1rxt, PDBj:1rxt
PDBsum1rxt
PubMed
UniProtP30419|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)

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