Structure of PDB 1r5v Chain C Binding Site BS01

Receptor Information

>1r5v Chain C (length=180) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EEHTIIQAEFYLLPDKRGEFMFDFDGDEIFHVDIEKSETIWRLEEFAKFA
SFEAQGALANIAVDKANLDVMKERSNNTPDANVAPEVTVLSRSPVNLGEP
NILICFIDKFSPPVVNVTWLRNGRPVTEGVSETVFLPRDDHLFRKFHYLT
FLPSTDDFYDCEVDHWGLEEPLRKHWEFEE

Ligand information

>1r5v Chain F (length=13) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ADLIAYPKAATKF

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1r5v Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation.
Resolution	2.5 Å
Binding residue (original residue number in PDB)	A52 S53 F54 G58 N62 V65 N69 V72 M73 R76
Binding residue (residue number reindexed from 1)	A50 S51 F52 G56 N60 V63 N67 V70 M71 R74

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0006955	immune response
GO:0019882	antigen processing and presentation

	Cellular Component
GO:0016020	membrane
GO:0042613	MHC class II protein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:1r5v, PDBe:1r5v, PDBj:1r5v
PDBsum	1r5v
PubMed	14690592
UniProt	P04224\|HA22_MOUSE H-2 class II histocompatibility antigen, E-K alpha chain

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