Structure of PDB 1r5t Chain C Binding Site BS01

Receptor Information
>1r5t Chain C (length=140) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVGGIEDRQLEALKRAALKACELSYSPYSHFRVGCSILTNNDVIFTGANV
ENASYSNCICAERSAMIQVLMAGHRSGWKCMVICGDSEDQCVSPCGVCRQ
FINEFVVKDFPIVMLNSTGSRSKVMTMGELLPMAFGPSHL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1r5t Chain C Residue 152 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1r5t The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C61 C96 C99
Binding residue
(residue number reindexed from 1)		C60 C95 C98
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.5: cytidine deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006216 cytidine catabolic process
GO:0006217 deoxycytidine catabolic process
GO:0008655 pyrimidine-containing compound salvage
GO:0009972 cytidine deamination
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0072527 pyrimidine-containing compound metabolic process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1r5t, PDBe:1r5t, PDBj:1r5t
PDBsum1r5t
PubMed15148397
UniProtQ06549|CDD_YEAST Cytidine deaminase (Gene Name=CDD1)

[Back to BioLiP]