Structure of PDB 1q7l Chain C Binding Site BS01

Receptor Information
>1q7l Chain C (length=190) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEHPSVTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPG
YVVTVLTWPGTNPTLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIY
ARGAQDMKCVSIQYLEAVRRLKVEGHRFPRTIHMTFVPDEEVGGHQGMEL
FVQRPEFHALRAGFALDEGIANPTDAFTVFYSERSPWWVR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1q7l Chain C Residue 1012 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1q7l Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		H80 D113 E175
Binding residue
(residue number reindexed from 1)		H73 D106 E168
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.1.14: N-acyl-aliphatic-L-amino acid amidohydrolase.
Gene Ontology
Molecular Function
GO:0004046 aminoacylase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006520 amino acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1q7l, PDBe:1q7l, PDBj:1q7l
PDBsum1q7l
PubMed12933810
UniProtQ03154|ACY1_HUMAN Aminoacylase-1 (Gene Name=ACY1)

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