Structure of PDB 1q1t Chain C Binding Site BS01

Receptor Information
>1q1t Chain C (length=427) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAG
LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFIS
LLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLS
TLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLA
DSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGN
IVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQ
IQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC
GIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGG
LDKIEALQRHENESVYKASLNLIEKYF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1q1t Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D280 G281 N283 R315 V321 T322 T328 E354 W357 S360 N361 E396 W399 S406
Binding residue
(residue number reindexed from 1)		D211 G212 N214 R246 V252 T253 T259 E285 W288 S291 N292 E327 W330 S337
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1q1t, PDBe:1q1t, PDBj:1q1t
PDBsum1q1t
PubMed12852786
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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