Structure of PDB 1q1s Chain C Binding Site BS01

Receptor Information

>1q1s Chain C (length=434) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MADIGSNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPID
NIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA
IPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALL
AVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHN
DPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPA
LRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT
AGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQI
VYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIM
IEECGGLDKIEALQRHENESVYKASLNLIEKYFS

Ligand information

>1q1s Chain A (length=5) Species: 1891767 (Betapolyomavirus macacae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KKRKV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1q1s Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha
Resolution	2.3 Å
Binding residue (original residue number in PDB)	V321 T322 T328 W357 S360 N361 E396 N403 S406
Binding residue (residue number reindexed from 1)	V258 T259 T265 W294 S297 N298 E333 N340 S343

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:1q1s, PDBe:1q1s, PDBj:1q1s
PDBsum	1q1s
PubMed	12852786
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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