Structure of PDB 1pzf Chain C Binding Site BS01
Receptor Information
>1pzf Chain C (length=326) Species:
5811
(Toxoplasma gondii) [
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PALVQRRKKVAMIGSGMIGGTMGYLCALRELADVVLYDVVKGMPEGKALD
LSHVTSVVDTNVSVRAEYSYEAALTGADCVIVTAGLTKVPGKPDSEWSRN
DLLPFNSKIIREIGQNIKKYCPKTFIIVVTNPLDCMVKVMCEASGVPTNM
ICGMACMLDSGRFRRYVADALSVSPRDVQATVIGTHGDCMVPLVRYITVN
GYPIQKFIKDGVVTEKQLEEIAEHTKVSGGEIVRFLGQGSAYYAPAASAV
AMATSFLNDEKRVIPCSVYCNGEYGLKDMFIGLPAVIGGAGIERVIELEL
NEEEKKQFQKSVDDVMALNKAVAALQ
Ligand information
Ligand ID
OXL
InChI
InChI=1S/C2H2O4/c3-1(4)2(5)6/h(H,3,4)(H,5,6)/p-2
InChIKey
MUBZPKHOEPUJKR-UHFFFAOYSA-L
SMILES
Software
SMILES
ACDLabs 10.04
CACTVS 3.341
[O-]C(=O)C([O-])=O
OpenEye OEToolkits 1.5.0
C(=O)(C(=O)[O-])[O-]
Formula
C2 O4
Name
OXALATE ION
ChEMBL
DrugBank
ZINC
PDB chain
1pzf Chain C Residue 406 [
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Receptor-Ligand Complex Structure
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PDB
1pzf
Structure of Toxoplasma gondii LDH1: Active-Site Differences from Human Lactate Dehydrogenases and the Structural Basis for Efficient APAD+ Use.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
W107 R109 R171 H195 G236
Binding residue
(residue number reindexed from 1)
W97 R99 R162 H186 G229
Annotation score
2
Enzymatic activity
Catalytic site (original residue number in PDB)
R109 D168 R171 H195
Catalytic site (residue number reindexed from 1)
R99 D159 R162 H186
Enzyme Commision number
1.1.1.27
: L-lactate dehydrogenase.
Gene Ontology
Molecular Function
GO:0000166
nucleotide binding
GO:0003824
catalytic activity
GO:0004459
L-lactate dehydrogenase activity
GO:0016491
oxidoreductase activity
GO:0016616
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process
GO:0006089
lactate metabolic process
GO:0006090
pyruvate metabolic process
GO:0019752
carboxylic acid metabolic process
View graph for
Molecular Function
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Biological Process
External links
PDB
RCSB:1pzf
,
PDBe:1pzf
,
PDBj:1pzf
PDBsum
1pzf
PubMed
14744130
UniProt
P90613
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