Structure of PDB 1py1 Chain C Binding Site BS01

Receptor Information
>1py1 Chain C (length=138) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQS
PQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRT
SEKVKNKILELLYSWTVGLPEEVKIAEAYQMLKKQGIV
Ligand information
Receptor-Ligand Complex Structure
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PDB1py1 Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K87 F88 R89 N92 I95 Y102 K131 M138 Q142
Binding residue
(residue number reindexed from 1)		K80 F81 R82 N85 I88 Y95 K124 M131 Q135
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0031267 small GTPase binding
GO:0035091 phosphatidylinositol binding
GO:0043130 ubiquitin binding
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0005802 trans-Golgi network

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1py1, PDBe:1py1, PDBj:1py1
PDBsum1py1
PubMed14567678
UniProtQ9UJY5|GGA1_HUMAN ADP-ribosylation factor-binding protein GGA1 (Gene Name=GGA1)

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