Structure of PDB 1mzn Chain C Binding Site BS01

Receptor Information

>1mzn Chain C (length=212) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DMPVERILEAELAVEPDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDD
QVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF
DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKV
YASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTP
IDTFLMEMLEAP

Ligand information

>1mzn Chain D (length=11) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KHKILHRLLQD

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1mzn Molecular Recognition of Agonist Ligands by RXRs
Resolution	1.9 Å
Binding residue (original residue number in PDB)	V1280 K1284 V1298 R1302 T1449 F1450 E1453
Binding residue (residue number reindexed from 1)	V34 K38 V52 R56 T203 F204 E207

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003707	nuclear steroid receptor activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:1mzn, PDBe:1mzn, PDBj:1mzn
PDBsum	1mzn
PubMed	11981034
UniProt	P19793\|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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