Structure of PDB 1lqb Chain C Binding Site BS01
Receptor Information
>1lqb Chain C (length=150) Species:
9606
(Homo sapiens) [
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PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIH
SYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKE
RCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQR
Ligand information
>1lqb Chain D (length=18) Species:
9606
(Homo sapiens) [
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EMLAPYIPMDDDFQLRSF
Receptor-Ligand Complex Structure
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PDB
1lqb
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
N67 R69 I75 N78 W88 F91 Y98 P99 G104 T105 G106 R107 R108 H110 S111 Y112 H115 W117
Binding residue
(residue number reindexed from 1)
N7 R9 I15 N18 W28 F31 Y38 P39 G44 T45 G46 R47 R48 H50 S51 Y52 H55 W57
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:1lqb
,
PDBe:1lqb
,
PDBj:1lqb
PDBsum
1lqb
PubMed
12050673
UniProt
P40337
|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)
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