Structure of PDB 1l7v Chain C Binding Site BS01

Receptor Information

>1l7v Chain C (length=231) Species: 562 (Escherichia coli)

SIVMQLQDVAESTRLGPLSGEVRAGEILHLVGPNGAGKSTLLARMAGMTS
GKGSIQFAGQPLEAWSATKLALHRAYLSQQQTPPFATPVWHYLTLHQHDK
TRTELLNDVAGALALDDKLGRSTNQLSGGEWQRVRLAAVVLQITPQANPA
GQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNHTLRHAH
RAWLLKGGKMLASGRREEVLTPPNLAQAYGM

Ligand information

• Ligand ID: V4O
• InChI: InChI=1S/12O.4V/q;;;;;;;;4*-1;;;;
• InChIKey: ACTPEXQBEHJTBO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.7.2: [O-][V]1(=O)O[V](=O)(O[V](=O)(O[V](=O)(O1)[O-])[O-])[O-]
  CACTVS 3.370: [O-][V]1(=O)O[V]([O-])(=O)O[V]([O-])(=O)O[V]([O-])(=O)O1
• Formula: O12 V4
• Name: CYCLO-TETRAMETAVANADATE
• DrugBank: DB02147
• PDB chain: 1l7v Chain C Residue 250

Receptor-Ligand Complex Structure

Structure summary

• PDB: 1l7v The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): N35 G36 A37 G38 K39 S40 T41
• Binding residue (residue number reindexed from 1): N34 G35 A36 G37 K38 S39 T40
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 7.6.2.8: ABC-type vitamin B12 transporter.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0015420 ABC-type vitamin B12 transporter activity
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity

Biological Process

• GO:0015889 cobalamin transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0019898 extrinsic component of membrane
• GO:0043190 ATP-binding cassette (ABC) transporter complex
• GO:1990191 cobalamin transport complex
• GO:1990193 BtuCD complex

External links

• PDB: RCSB:1l7v, PDBe:1l7v, PDBj:1l7v
• PDBsum: 1l7v
• PubMed: 12004122
• UniProt: P06611|BTUD_ECOLI Vitamin B12 import ATP-binding protein BtuD (Gene Name=btuD)