Structure of PDB 1jke Chain C Binding Site BS01

Receptor Information
>1jke Chain C (length=145) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIALIQRVTRASVTVEGEVTGEIGAGLLVLLGVEKDDDEQKANRLCERVL
GYRIFSDAEGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPSFSKGASPD
RAEALYDYFVERCRQQEMNTQTGRFAADMQVSLVNDGPVTFWLQV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain1jke Chain C Residue 905 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1jke Structure of crystalline D-Tyr-tRNA(Tyr) deacylase. A representative of a new class of tRNA-dependent hydrolases.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		E103 D107
Binding residue
(residue number reindexed from 1)		E103 D107
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Q78 F79 T80
Catalytic site (residue number reindexed from 1) Q78 F79 T80
Enzyme Commision number 3.1.1.96: D-aminoacyl-tRNA deacylase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0002161 aminoacyl-tRNA editing activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042803 protein homodimerization activity
GO:0043908 Ser(Gly)-tRNA(Ala) hydrolase activity
GO:0051499 D-aminoacyl-tRNA deacylase activity
GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity
GO:0106026 Gly-tRNA(Ala) hydrolase activity
Biological Process
GO:0006399 tRNA metabolic process
GO:0009408 response to heat
GO:0019478 D-amino acid catabolic process
GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jke, PDBe:1jke, PDBj:1jke
PDBsum1jke
PubMed11568181
UniProtP0A6M4|DTD_ECOLI D-aminoacyl-tRNA deacylase (Gene Name=dtd)

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