Structure of PDB 1fcj Chain C Binding Site BS01

Receptor Information
>1fcj Chain C (length=304) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKIYEDNSLTIGHTPLVRLNRIGNGRILAKVESRNPSFSVKCRIGANMIW
DAEKRGVLKPGVELVEPTNGNTGIALAYVAAARGYKLTLTMPETMSIERR
KLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPQKYLLLQQFSNPANPE
IHEKTTGPEIWEDTDGQVDVFISGVGTGGTLTGVTRYIKGTKGKTDLITV
AVEPTDSPVIAQALAGEEIKPGPHKIQGIGAGFIPGNLDLKLIDKVVGIT
NEEAISTARRLMEEEGILAGISSGAAVAAALKLQEDESFTNKNIVVILPS
SGER
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain1fcj Chain C Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1fcj Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		T68 G70 T72 Q142
Binding residue
(residue number reindexed from 1)		T68 G70 T72 Q142
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K41 G228 S272
Catalytic site (residue number reindexed from 1) K41 G228 S272
Enzyme Commision number 2.5.1.47: cysteine synthase.
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1fcj, PDBe:1fcj, PDBj:1fcj
PDBsum1fcj
PubMed11023792
UniProtP0A1E3|CYSK_SALTY Cysteine synthase A (Gene Name=cysK)

[Back to BioLiP]