Structure of PDB 1ca0 Chain C Binding Site BS01

Receptor Information

>1ca0 Chain C (length=97) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ANTPDRLQQASLPLLSNTNCKKYWGTKIKDAMICAGASGVSSCMGDSGGP
LVCKKNGAWTLVGIVSWGSSTCSTSTPGVYARVTALVNWVQQTLAAN

Ligand information

>1ca0 Chain A (length=11) Species: 9913 (Bos taurus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

CGVPAIQPVLS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	1ca0 Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	Q157 A206 W207
Binding residue (residue number reindexed from 1)	Q9 A58 W59

Enzymatic activity

Catalytic site (original residue number in PDB)	M192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1)	M44 G45 D46 S47 G48
Enzyme Commision number	3.4.21.1: chymotrypsin.

Gene Ontology

	Molecular Function
GO:0004252	serine-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:1ca0, PDBe:1ca0, PDBj:1ca0
PDBsum	1ca0
PubMed	9300481
UniProt	P00766\|CTRA_BOVIN Chymotrypsinogen A

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