Structure of PDB 1bd4 Chain C Binding Site BS01
Receptor Information
>1bd4 Chain C (length=224) Species:
5811
(Toxoplasma gondii) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
QEESILQDIITRFPNVVLMKQTAQLRAMMTIIRDKETPKEEFVFYADRLI
RLLIEEALNELPFQKKEVTTPLDVSYHGVSFYSKICGVSIVRAGESMESG
LRAVCRGVRIGKILIQRDETTAEPKLIYEKLPADIRERWVMLLDPMCATA
GSVCKAIEVLLRLGVKEERIIFVNILAAPQGIERVFKEYPKVRMVTAAVD
ICLNSRYYIVPGIGDFGDRYFGTM
Ligand information
Ligand ID
PO4
InChI
InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKey
NBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
Software
SMILES
CACTVS 3.341
[O-][P]([O-])([O-])=O
ACDLabs 10.04
[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0
[O-]P(=O)([O-])[O-]
Formula
O4 P
Name
PHOSPHATE ION
ChEMBL
DrugBank
DB14523
ZINC
PDB chain
1bd4 Chain C Residue 799 [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
1bd4
Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
R137 A168 T169 G171 S172
Binding residue
(residue number reindexed from 1)
R117 A148 T149 G151 S152
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
R137 T141 D235 D238
Catalytic site (residue number reindexed from 1)
R117 T121 D215 D218
Enzyme Commision number
2.4.2.9
: uracil phosphoribosyltransferase.
Gene Ontology
Molecular Function
GO:0004845
uracil phosphoribosyltransferase activity
GO:0005525
GTP binding
GO:0016757
glycosyltransferase activity
Biological Process
GO:0044206
UMP salvage
Cellular Component
GO:0005737
cytoplasm
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1bd4
,
PDBe:1bd4
,
PDBj:1bd4
PDBsum
1bd4
PubMed
9628859
UniProt
Q26998
|UPP_TOXGO Uracil phosphoribosyltransferase (Gene Name=uprt)
[
Back to BioLiP
]