Structure of PDB 1b49 Chain C Binding Site BS01

Receptor Information
>1b49 Chain C (length=241) Species: 10665 (Tequatrovirus T4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFG
ALNDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAI
WSEDNYAQYDMCLAELGQNPDSRRGIMIYTRPSMQFDYNKDGMSDFMCTN
TVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLNAGDST
RQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKDY
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain1b49 Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1b49 Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K28 R168 S169
Binding residue
(residue number reindexed from 1)		K28 R168 S169
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E60 C148 D179
Catalytic site (residue number reindexed from 1) E60 C148 D179
Enzyme Commision number 2.1.2.8: deoxycytidylate 5-hydroxymethyltransferase.
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0047153 deoxycytidylate 5-hydroxymethyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1b49, PDBe:1b49, PDBj:1b49
PDBsum1b49
PubMed10064578
UniProtP08773|DCHM_BPT4 Deoxycytidylate 5-hydroxymethyltransferase (Gene Name=42)

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