Structure of PDB 4v8m Chain Bu Binding Site BS01

Receptor Information
>4v8m Chain Bu (length=298) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFVKVVKNKAYYKRFQVKYRRRREGKTDYHARRRMVLQDKTKFGTPKYRL
VVRITNRDVIAQIVHAKVVGDEVVMAAYSHELPLFGIEHGLTNYAAAYAT
GLLVARRMLAKLGLAEKFVGVKEVDGSYAAVRTKDDDQGDDESRFPFKAI
LDVGLARTTTGARVFGVLKGAVDGGLAVPHRPNRFPGYNKESDALNAKVH
RDRIFGRHVADYLKQVREEASSNPDEKTCQFSKFIAAKVSPDDMEGMYKR
AHAAIRADPTKRRAKKERPAEAKPKKYNTVKLTGAEKKAAAKAKVAAV
Ligand information
>4v8m Chain BA (length=1847) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cagaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucag
cggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaaga
gggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggc
accauuuuuguggccguucuuauagggcuggugcaggcguggcggaauuc
aauugcaaagcaaacccguugcugaacacauuuacaacccuucaugugag
uauugagccaaagaaggugucagcccauuacauuccuuagccacggagcc
uacgcgccuccucauguucgguccaagagaguagcacuguuugggaaugc
agugucaagccggcagguauuugucugccaagguuaaauauagaguagga
agaccgauagcgaacaaguagcgugagcgaaaguuugaaaaguacuuugg
aaagagagugacauagaaccugaaaucgugacaacgacaauggaaguacc
uucauuucuuuuuuuuacggccagacccaaccucgccgcgcaauuucggu
ucaacauccuucacugugcggguuucucuuuugaggucauggggugcgug
agugggcggaauaaagggucgguguguuguguguggguuuuuucucucac
ucucuuccuccuucccuguucgugcgucucgacgcuggcgauggaaaugg
ggugcccccacccgucuugaaacacggaccaaggagucaaacagacgcgc
aagggaggaguauguaugugagaacucuuuucucguacugaaagggagag
ugugauuuuacacccguggcgugcgcaauuucucuuuuuuguguuuuugc
ccaacgccggccggccccccgugggcugcgcgcgagugugccuguuugga
cccgaaagguggugaacuaugccugaacaaggugaagcccggggaaaccc
cgguggaggccuguagcgaugcugacgugcaaaucgcucguacgauuugg
guaucggagcgaaagacucaucgaaccaccuaguagcugguucacgucga
aguuucccucaggauagcuggugcuugucuuuaagaaguauugugcggua
aagcaaaugauuagaggcauugguguucuuguaauaucgaccuauucuca
aacuuuaaaugugcaaacaacccagccuuaguuauuuuaacaaggcuuuu
ggguacauaagaauugaggcaccaagugggccuucuucgguaagcggagc
aggcgaugcggaaugaaccgcuuagggauauguggcgucaaaacuugugg
gcucauucucgauacgugaaaaggguguugguggauagggacaguuggac
gguggccauggaagucggcauccgcuaaggaguguguaacaacucaccaa
ccgaauccaccggccccgaaaauggaugacgcuuaagccccaugugcgug
auugcccauuauuccuuuggugagggcggcuauauuucuuugugagaaag
uguagcccucccgauguagacguggcgugggggugaggacgaagccgaug
gcgcgagccucggauggacccgccucuagugcagaucuugguuggcguag
caaagaucuaacggaauauuuuuucuuaaaugcaacguuggauacuggag
cggggaaggauuucgugccaacggcacucguacacgaguuguucggucac
ugagcacaacguuacaccguuuuguuaggaaagugaagguggucggcgca
caucucccuuuuuugggguuuguguguuuuaccggcuuaucugaaaaggg
gcaacagagaaccugggaugauauuccaaaaagaaauugcauguggg
........................<<<<<.....<......>......>>
>>>...........<......>...<<<<<......<<.....>>....>
>>>>....<<<............<<<<<......>>>>>...........
................<<..<..<<<<..<<<<<<<<.<<<<<.......
.<.<<...<<<<<.....>>>>>....<<<<............>>>>...
>>.>..(........<<......)>>.............>>>>>....>>
>..>>>>>>>>>...>...>>............<<<<<<<........>>
>>>>>......<<<<<........>>>>>..>>>................
....................<<....>>................<<<...
...>>>...................................<<..<<<<.
..<<<<<....<..<<.....<<..<.<<.....<.<<<<<<.<......
............>.>>>>>..>.>.......>>.>....>>.........
.......<<<.<....<<..<.........<<<.<<<......>>>.>>>
..........>..>>..>>>>...............>>.>....>>>>>.
.>>>>..>>..<<<<........>>>><<<<<<.....<<.<<<.<<<<<
..<<<...<<................>>...>>>...<<....>>....<
<<<<....>>>>>...<<<...<<<<<<..........>>>>>>......
>>>.<<<<<<<<...........>>>>>.>>>...>>>>>.>>>.>>...
<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<.<<<....>>>
.>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>
>>>>...<<.......>>......>>>>>>......>.>>...<<<<<..
....<<<....>>><.<.<<<<<<<.........<<....<<<<<<<...
<<<....<<<..<.<<<....<<<<<<.....>>>>>>..>>>.>..>>>
..>>.>...>>>>>>>...<<<<<<<<<<.<<.......>>>>>>>>...
>>>>.........>>..>>>>>>>..>>.<<<<.<<<<<.....>>>>>.
>>>>...<<<<......>>>>..<<<<<<<...<<<(((.........<<
<<........<...........<<<.<<<<<<<<<........<<<<<.<
<....<<.........>>....>>.........<<......>>...>>>>
>....>>>>>>>>>>>>..........))).>....>>>>..........
...>>>...>>>>>>><<<<.<<<<<.....<<<<..............>
>>>..>>>>>>>>>....>>>>>.....<<<<<<..<.......<<<..<
<<....>>>.>>>......>.>>>>>>.........>>>>>>........
......<<<<<<......<<........>>......>>>>>>........
............<<<<<....<<.....>>..>>>>>....<<......<
...<<..<<<<......>>>>..........<<..<<<.<<<<.<.<<<<
<<..<<<<......>>>>..>>>>>>..>.>>>>.>>>..>>........
>>....>.....<<<...........>....>>.>>...........
Receptor-Ligand Complex Structure
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PDB4v8m High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome.
Resolution5.57 Å
Binding residue
(original residue number in PDB)		K5 K10 A11 R15 F44 T46 K118 V132 R133 T134 E143 S144 R145 F146 P147 K149
Binding residue
(residue number reindexed from 1)		K4 K9 A10 R14 F43 T45 K117 V131 R132 T133 E142 S143 R144 F145 P146 K148
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008097 5S rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0006412 translation
GO:0042255 ribosome assembly
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v8m, PDBe:4v8m, PDBj:4v8m
PDBsum4v8m
PubMed23395961
UniProtQ38CY8

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