Structure of PDB 8p2k Chain Bt Binding Site BS01

Receptor Information
>8p2k Chain Bt (length=156) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRI
TVKLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDE
IVNIARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSG
AVECPA
Ligand information
>8p2k Chain B5 (length=3764) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaau
guggcguacggaagacccacuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcgugguccggccgugccggcg
gucucggcggaucuuucccgcuccccguuccuggggguggggucggcggg
ggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgc
ggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcgggg
aagguggcccggggggacgccucgccgccgucguccgcggcggcggcggg
cgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgc
cgaaucccggggccgagggagcgagaccugugucgccgcgcucucccccc
ucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacu
guccccagugcgccccgggcgugucacgccgucgggcucgggggaggcca
cggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggc
ggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagu
cuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaau
gaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccga
ggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgc
gccggggagguggagcacgagcgcacguguuaggacccgaaagaugguga
acuaugccugggcagggcgaagccagaggaaacucugguggagguccgua
gcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaag
acuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggau
agcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauua
gaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggg
uaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccu
agugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacg
ccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaaggugu
ugguugauauagacagcaggacgguggccauggaagucggaauccgcuaa
ggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaug
gcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagc
gagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggcc
gcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgc
aggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaag
gccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagu
cgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccu
ccguugcccucagccgaucgaaagggagucggguucagauccccgaaucc
ggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccg
aucccggagaagccggcgggagccccggggagaguucucuuuucuuugug
aagggcagggcgcccuggaauggguucgccccgagagaggggcccgugcc
uuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccu
ugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauau
ccgcagcaggucuccaaggugaacagccucuggcauguuggaacaaugua
gguaagggaagucggcaagccggauccguaacuucgggauaaggauuggc
ucuaagggcugguagcagccgacuuagaacuggugcggaccaggggaauc
cgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguuga
cgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauuca
augaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcc
aaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauu
cccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggc
uuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucu
ggcacggugaagagacaugagagguguagaauaagugggaggcccgggcc
gccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggc
gggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggcc
ccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagu
gccagguggggaguuugacuggggcgguacaccugucaaacgguaacgca
gguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaa
gggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaa
agcggggccucacgauccuucugagcuuuuggguuuuaagcaggaggugu
cagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucaua
gcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaa
gcagaauucaccaagcguuggauuguucacccacuaauagggaacgugag
cuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaugu
guuguugccaugguaauccugcucaguacgagaggaaccgcagguucaga
cauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccauc
ugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaa
cgauacggcagcgccgaaggagccucgguuggccucggauagccgguccc
ccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggc
cggaaagggggccgcccucucgcccgucacgcaccgcacguucgugggga
accuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucg
uacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucg
acacaaggguuugu
.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....
>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>...<<<<<<<<<....<<<<<<<<.<<<....<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....<<<<<..((((((>>>>>..>>>..................
................<<....>>...............<<<<....>>>
>..................................<<<<<<<<..<<<.<
<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<
.....<<<<<.<<<..<<<<<<<<<<<<<<....>>>>>>>>..>>>>>>
>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.
>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<
......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>
........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>
>>...>>>>>>>>>>.....<<.....[[>>......<<<<<<.<<<<<<
<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<
<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.
>><<<<<.<<<<<<<..>>>>>>>>>>>>....>>>>>>......>>.>>
>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<....
<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<
....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..
<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<....
..>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<<<..
...<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...
<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<......
.>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.
><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<...
.<<<..<<<<<<.<.....>.>>>>>>>>>....>>>..>.>>...>>>>
>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.
.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<
<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<
<<<<<<<<.......<<<<<.<<....<<.........>>....>>....
.....<<......>>...>>>>>...>>>>>>>>>>>>>..........)
)).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...
........}}.))))..............>>>>>>>>>....>>>>>>..
.<<<<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>
>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.
<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((
<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...
>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<
<<....<<<<<...<<<<<<<....>>>>>>>...<<<....>>>...<.
.<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>...
.<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>
>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>...
......>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....
<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<
<<<<.<<...............<<<<<...............>>>>><<.
<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<
<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>.....
.>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<....>>>>
.....>>>.>>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<.......>>>>>.....>.....>>....>>.>>>>
>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........>
>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<
<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<..<<<<..>>>>
............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<
<<<..<<.<<<<<<<..>>>>>>>>>..............<<<<<.<<<<
<<<<<<<<<..>>>>>>>>>.>>>>.>>>>>..>>>>..>>>>>....>>
>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>
>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(
((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>.<<<...
.>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>...
......>>>>..>>>>>>.......<<.<...<<<<<<...<<.......
>>...>>>>>>....>.>.>.......<<<<<.<<<<<<..<.<.<<<<<
......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>
>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....
<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<
....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>
>><<<<....<<<<<...........>>>>>....>>>>.>>>...>.>>
>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<
<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<
<........>>>>>>>>>>...>>>>..>>>..............>>>>.
.>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<..
...<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>
>>.>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p2k NAC controls cotranslational N-terminal methionine excision in eukaryotes.
Resolution2.9 Å
Binding residue
(original residue number in PDB)
Y14 R16 T25 R57 S76 A77 S78 R92 K96 N97 I98 R119 L121 A122 R123 K130 E131 G134 T135 Q137 S138
Binding residue
(residue number reindexed from 1)
Y6 R8 T17 R49 S68 A69 S70 R84 K88 N89 I90 R111 L113 A114 R115 K122 E123 G126 T127 Q129 S130
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8p2k, PDBe:8p2k, PDBj:8p2k
PDBsum8p2k
PubMed37347872
UniProtG1SMR7|RL12_RABIT Large ribosomal subunit protein uL11 (Gene Name=RPL12)

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