Structure of PDB 8ove Chain Br Binding Site BS01

Receptor Information
>8ove Chain Br (length=366) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSVSVYSASEDKVVGTCSLPAVFTAPIRHDVVQFVHTNMAKNSRQPYAVN
RLSGMKHSAESWGTGRAVARIPRIHGGGTSMSGAGAFGNMCRGGRMFAPT
KIFRRWHRKINLHQKRFAVVSALAASSLPALVMSRGHKIENVAEVPLVVE
DGVRAYEKTKEAMTFLKTVGAIDDVNRVNDSRQIRAGRGKMRNRRYVARR
GPMLVMPDNKGTRAFRNIFGLDLANVNSLNLLHLAPGGHVGRFIIWTKSA
FEKLDKIFGTFTEPSTVKSGFMLPAPMLTSTDVTRIMQSEEVRRVLKPKK
LQPKRPSRYRQPTNGIRNRRLRLRLNPFQKKEKAMAKGMQNKKNREARHA
AKVVRLAKARKNVAKA
Ligand information
>8ove Chain BA (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauacaacccuucaugugaguauugagccaaagaaggugucagccc
auuacagccacggagccuacgcgccuccucaagagaguagcacuguuugg
gaaugcagugucaagccggcagguauuugucugccaagguuaaauauaga
guaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagua
cuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugga
aguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuucc
ggggcuaacauccgguggguacugugcggguuucgaggucauggggugcg
ugagugggcggaauaaagggucggugguuguguucuuccuccuucccugu
ccgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggaguauugugac
aacuuuucucguacugaaagggaggugugauacacccguggcgugcgcaa
uuuguguuuuugcccaacaccgaccggcgugggcugcgcgcgagugugcc
uguuuggacccgaaagguggugaacuaugccugaacaaggugaagcccgg
ggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgcucgua
cgauuuggguaucggagcgaaagacucaucgaaccaccuaguagcugguu
cacgucgaaguuucccucaggauagcuggugcuuguuaagaaguauugug
cgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaugugcaa
acaacccagccuuaguuauaacaaggcuggguaauugaggcaccaagugg
gccuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggau
auguggcgucaaaacuugugggcucauucucgauacgugaaaaggguguu
gguggauauccaccggccccgaaaauggaugacgcuuaagccccaugugc
gugauugcccauuauuccuuuggugagggcggcuauaugugagaaagugu
agcccucccgauguagacguggcgugggggugaggacgaagccgauggcg
cgagccucggauggacccgccucuagugcagaucuugguuggcguagcaa
agaucuaacggaauauuuuuaaaugcaacguuggauacuggagcggggaa
ggauuucgugccaacggcacucguacacgaguuguucggucacugagcac
aacguuacaccguuuuguuaggaaagaaaaggggcaacagagaaccuggg
augauauuccaaaaagaauugcauguggg
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>.......<<........>>......>>>.<<.......((.....>>))
......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<....
....>>>>>>>......<<<<<........>>>>>..>>>..........
..........................<<....>>................
<<<<....>>>>..................................<<<.
.<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<<
<<<.......>>>>>.>>>....>>>>>>....>>>>>>..>>>......
........<<<<....<<<<..<<.<<..<....>..>>.>>..>>>>.>
>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<........
.>>>...>>>...<<....>>..<<<<<...>>>>>......<...<.<.
......>.>....>.....<<<.<<......>>.>>.>.....>>>>>.>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<
<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
.<<<<<....<.<<<....>>>.><<<<<<<<<.......<<.<.<<<<<
<....<<<....<<<....<<<..>>>....>>>..>.>>....>>>>>>
...<<<<<<<<<<.<<<..>>>>>>>>>>>>>.>>>..>>>>>>>.>>..
<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<
<...<<<(((......<<.<<<<........<...........<<<.<<<
<<<<<<..>>>>>>>>>>>>..........))).>....>>>>>>.....
......>>>...>>>>>>><<<<.<<<<<..........>>>>>......
..>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<.
...>>>.>>>.>.....>>>>>>>>..>.....>>>>>>...........
...<<<<<<<..................>>>>>>>...............
.....<<<<<....<<.....>>..>>>>>.....<..........<<.<
<<<<......>>>>.................>.>>..........<<<<.
........>>....>>.>...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)
R32 F38 T41 M43 N46 R48 Q49 Y51 L56 S57 M59 K60 H61 S62 V72 R74 P76 G81 G82 T83 A88 N93 M94 R96 G97 R99 M100 F101 A102 K105 F107 R109 N115 H117 Q118 R120 R139 E144 N145 K162 T163 K164 R181 R189 A190 G191 R192 K194 R196 N197 R198 Y200 R203 R204 R217 R220 N221 D226 S232 N234 H237 G241 H243 V271 K272 S273 R297 Q306 R309 R312 Y313 R314 T317 N318 R321 N322 R323 R324 L327 K334 K335 K337 K341 Q344 K347 N348 R349 R352 K356 A361 A363 R364 K365 N366 V367
Binding residue
(residue number reindexed from 1)
R28 F34 T37 M39 N42 R44 Q45 Y47 L52 S53 M55 K56 H57 S58 V68 R70 P72 G77 G78 T79 A84 N89 M90 R92 G93 R95 M96 F97 A98 K101 F103 R105 N111 H113 Q114 R116 R135 E140 N141 K158 T159 K160 R177 R185 A186 G187 R188 K190 R192 N193 R194 Y196 R199 R200 R213 R216 N217 D222 S228 N230 H233 G237 H239 V267 K268 S269 R293 Q302 R305 R308 Y309 R310 T313 N314 R317 N318 R319 R320 L323 K330 K331 K333 K337 Q340 K343 N344 R345 R348 K352 A357 A359 R360 K361 N362 V363
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ582N2

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