Structure of PDB 7o81 Chain Bp Binding Site BS01

Receptor Information
>7o81 Chain Bp (length=91) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRA
VGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ
Ligand information
>7o81 Chain B5 (length=3764) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcgguggggcgcgggaaau
guggcguacggaagacccacuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcgugguccggccgugccggcg
gucucggcggaucuuucccgcuccccguuccuggggguggggucggcggg
ggaccgccccccggccggcgaccggccgccgccgggcgcauuuccaccgc
ggcggugcgccgcgaccggcuccgggacggcugggaaggccccggcgggg
aagguggcccggggggacgccucgccgccgucguccgcggcggcggcggg
cgcgaccccuccccggguguuacagccccgccccggcagcagcagcucgc
cgaaucccggggccgagggagcgagaccugugucgccgcgcucucccccc
ucgggggggccgggccgccccucccacggcgcgaccgcucggggcggacu
guccccagugcgccccgggcgugucacgccgucgggcucgggggaggcca
cggcgcgucgcgcgccggcgcgcgcgcgcgagcgagcgcacggggucggc
ggcgaugucggcuacccacccgacccgucuugaaacacggaccaaggagu
cuaacacgugcgcgagucgggggcucgcacgaaagccgccguggcgcaau
gaaggugaaggccggcggcggcgccgucgucggccgaggugggaucccga
ggcccuuccaguccgccgagggcgcaccaccggcccgucucgcccgccgc
gccggggagguggagcacgagcgcacguguuaggacccgaaagaugguga
acuaugccugggcagggcgaagccagaggaaacucugguggagguccgua
gcgguccugacgugcaaaucggucguccgaccuggguauaggggcgaaag
acuaaucgaaccaucuaguagcugguucccuccgaaguuucccucaggau
agcuggcgcucucgcaaccccgcaguuuuauccgguaaagcgaaugauua
gaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaauggg
uaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugccu
agugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaacg
ccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaaggugu
ugguugauauagacagcaggacgguggccauggaagucggaauccgcuaa
ggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggaug
gcgcuggagcgucgggcccauacccggccgucgcuggcagucggcagagc
gagaaagagaguggagccgcggacgcuacgccgcgacgaguaggagggcc
gcugcggugagccuugaagccuagggcgcgggcccggguggagccgccgc
aggugcagaucuuggugguaguagcaaauauucaaacgagaacuuugaag
gccgaaguggagaaggguuccaugugaacagcaguugaacaugggucagu
cgguccugagagaugggcgagcgccguuccgaagggacgggcgauggccu
ccguugcccucagccgaucgaaagggagucggguucagauccccgaaucc
ggaguggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccg
aucccggagaagccggcgggagccccggggagaguucucuuuucuuugug
aagggcagggcgcccuggaauggguucgccccgagagaggggcccgugcc
uuggaaagcgucgcgguuccggcggcguccggugagcucucgcuggcccu
ugaaaauccgggggagaggguguaaaucucgcgccgggccguacccauau
ccgcagcaggucuccaaggugaacagccucuggcauguuggaacaaugua
gguaagggaagucggcaagccggauccguaacuucgggauaaggauuggc
ucuaagggcugguagcagccgacuuagaacuggugcggaccaggggaauc
cgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggguguuga
cgcgaugugauuucugcccagugcucugaaugucaaagugaagaaauuca
augaagcgcggguaaacggcgggaguaacuaugacucucuuaagguagcc
aaaugccucgucaucuaauuagugacgcgcaugaauggaugaacgagauu
cccacugucccuaccuacuauccagcgaaaccacagccaagggaacgggc
uuggcggaaucagcggggaaagaagacccuguugagcuugacucuagucu
ggcacggugaagagacaugagagguguagaauaagugggaggcccgggcc
gccggugaaauaccacuacucuuaucguuuuuucacugacccggugaggc
gggggggcgagccccgaggggcucucgcuucuggcgccaagcgccgggcc
ccgucgguccgggccggcggcggccgggcgcgacccgcuccggggacagu
gccagguggggaguuugacuggggcgguacaccugucaaacgguaacgca
gguguccuaaggcgagcucagggaggacagaaaccucccguggagcagaa
gggcaaaagcucgcuugaucuugauuuucaguacgaauacagaccgugaa
agcggggccucacgauccuucugagcuuuuggguuuuaagcaggaggugu
cagaaaaguuaccacagggauaacuggcuuguggcggccaagcguucaua
gcgacgucgcuuuuugauccuucgaugucggcucuuccuaucauugugaa
gcagaauucaccaagcguuggauuguucacccacuaauagggaacgugag
cuggguuuagaccgucgugagacagguuaguuuuacccuacugaugaugu
guuguugccaugguaauccugcucaguacgagaggaaccgcagguucaga
cauuugguguaugugcuuggcugaggagccaauggggcgaagcuaccauc
ugugggauuaugacugaacgccucuaagucagaaucccgcccaggcggaa
cgauacggcagcgccgaaggagccucgguuggccucggauagccgguccc
ccgcgggguccggugcggagagcccuucgucccgggaaauggggcgcggc
cggaaagggggccgcccucucgcccgucacgcaccgcacguucgugggga
accuggcgcuaaaccauucguagacgaccugcuucugggucgggguuucg
uacguagcagagcagcucccucgcugcgaucuauugaaagucagcccucg
acacaaggguuugu
.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....
>>>>>>..<<<..<<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>>..<<<<<<<<<....<<<<<<<.<<<<....<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>>>>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....<<<<<..((((((>>>>>..>>>..................
................<<....>>...............<<<<....>>>
>..................................<<<<<<<<..<<<.<
<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<
.....<<<<<.<<<..<<<<<<<<<<<<<<<..>>>>>>>>>..>>>>>>
>>>>>>>>.>>>>>>>>>>...>>>.>>>>>>>>>>......>>>.>>>.
>>>>>...<<<<<<<.<<<<<<<<<<.<<<<...<<..<<<..<<<<<<<
......<<<<<<<<<<....<<<<<<<<<<<<<<..>>>>>>>>>>>>>>
........>>>>>>>>>>.......>>>>>>>..>>>.........>>>>
>>...>>>>>>>>>>.....<<.....[[>>......<<<<<<.<<<<<<
<.>>>>>>>.<<<<<<.<<<<.<<<<<<<<<.<<<<<<<<<<<<<<.<<<
<....>>>>.>>>>>>>>>>>.>>>.>>>>>>.>>>...>>>>..>>>>.
>><<<<<.<<<<<<<..>>>>>>>>>>>>....>>>>>>......>>.>>
>>>...>>>>>...>>>>>>>>..<<<<........>>>><<<<<<...<
<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>>>...<<
....>>...<<<<<<<<<<<<..>>>>>>>>>>>>..<<<<<...<<<..
<<....((((.{{..>>..>>>....>>>>>.<<<<<<<<<.<<<<....
..>>>>>>>>>>>.>>....>>>>>>>>>>>>>>.<<.<..<<<<<<<..
...<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...
<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<......
.>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.
><<.<<<<<<<..........<<<.<<<<<<<<<...<<<....<<<..<
.<<<..<<<<<<.<.....>.>>>>>>>>>.>..>>>..>.>>...>>>>
>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.
.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<
<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<<
<<<<<<<<.......<<<<<.<<....<<.........>>....>>....
.....<<......>>...>>>>>...>>>>>>>>>>>>>..........)
)).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......]]...
........}}.))))..............>>>>>>>>>....>>>>>>..
.<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>>>>
>>........>>>>>><<.....<<.....<<<<<<.......>>>>>>.
<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((
<<<<<<...<<....<<<....>>>..........<<.<<<<<<<<<...
>>>>>>>>>>>......>>....>>>..<<<<<........>>>>>))<<
<<....<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<.
.<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>...
.<<<<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>
>>.....<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>...
......>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....
<<......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<
<<<<.<<.........<.....<<<<<....<<..>>.....>>>>><<.
<<<<<<<<<<<....>>>>>..>>>>>>.>>............<<<<<<<
<<..<<<.........>>>..<<<<<<<....<<<<.....>>>>.....
.>>>>>>>...<<..<<<..<<<<<<.<..<<<.....<<<<....>>>>
.....>>>>>>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<.......>>>>>.....>.....>>....>>.>>>>
>>>..>..>>.>>>>>>>..>>>>>>....>>....<<<<<........>
>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<
<<<<<.<<<<<<<<<<<<<<<<<..........<<<<<..<<<<..>>>>
............>>>>>.>>>>>>>.>>>>>>>>>>...<<<<<.....<
<<<..<<.<<<<<<....>>>>>>>>..............<<<<<.<<<<
<<<<<<<<<..>>>>>>>>>.>>>>.>>>>>..>>>>..>>>>>....>>
>>>>>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>
>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.....<<.[.(
((>>....>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<...
.>>>.>>)))].....<<<<<<<..<<<..)))))).>>>>>>>>>>...
......>>>>..>>>>>>.......<<.<.<.<<<<<<...<<.......
>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<.<.<<<<<
......>>>>>...>.>.<<<.........>>>.....>>>>>..>...>
>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....
<<<<<<.<..<<<..<.<<<<<.................>>>>>.><<<<
....<<<<....<<.<<<<<<.]]]..>>>>..>>.>>...>>>>...>>
>><<<<<...<<<<<...........>>>>>...>>>>>.>>>...>.>>
>>>>.....<<<<<<<..<<..<<<<....<<<........<<<<<..<<
<<..>>>>.>>>>>.......>>>...<<<..<<<<....<<<<.<<<<<
<........>>>>>>>>>>...>>>>..>>>..............>>>>.
.>>>>>>>>><<<<<.<.............>....<<.<<<<<<<.<<..
...<<<<.<..<<<<<......>>>>>..>>>>>....>>....>>>>.>
>>.>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7o81 Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
Resolution3.1 Å
Binding residue
(original residue number in PDB)
A2 R4 T5 K7 V8 G9 I10 G12 K13 Y14 G15 T16 R17 Y18 G19 A20 S21 R23 H34 F41 C42 K44 K46 R49 R50 G58 S59 W69
Binding residue
(residue number reindexed from 1)
A1 R3 T4 K6 V7 G8 I9 G11 K12 Y13 G14 T15 R16 Y17 G18 A19 S20 R22 H33 F40 C41 K43 K45 R48 R49 G57 S58 W68
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7o81, PDBe:7o81, PDBj:7o81
PDBsum7o81
PubMed34029205
UniProtG1SY53|RL37A_RABIT Large ribosomal subunit protein eL43 (Gene Name=RPL37A)

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