Structure of PDB 8ova Chain Bo Binding Site BS01

Receptor Information
>8ova Chain Bo (length=89) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKRTVKMGVMGRYGARYGSNPRKRAKKLEVSQHAKHFCSFCGKFAFRRKA
VGIWRCDGCSKTVAGGAYTLSTPNNTTVRSTVRRLRELK
Ligand information
>8ova Chain BA (length=1604) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauuacaacccuucaugugaguauugagccaaagaaggugucagcc
cauuacagccacggagccuacgcgccuccucaagagaguagcacuguuug
ggaaugcagugucaagccggcagguauuugucugccaagguuaaauauag
aguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagu
acuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugg
aaguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuuc
cggggcuaacauccggugggucacugugcggguuucgaggucauggggug
cgugagugggcggaauaaagggucgguguguuguguucuuccuccuuccc
uguccgugcgucucgacgcuggcgauggaaauggggugcccccacccguc
uugaaacacggaccaaggagucaaacagacgcgcaagggaggaguauugu
gacaacucuuuucucguacugaaagggaggugugauacacccguggcgug
cgcaauuuuuugcccaacaccgaccggcccuccgugggcugcgcgcgagu
gugccuguuuggacccgaaagguggugaacuaugccugaacaaggugaag
cccggggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgc
ucguacgauuuggguaucggagcgaaagacucaucgaaccaccuaguagc
ugguucacgucgaaguuucccucaggauagcuggugcuugucaagaagua
uugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaug
ugcaaacaacccagccuuaguuauuuuaacaaggcuuuaagaauugaggc
accaagugggccuucuucgguaagcggagcaggcgaugcggaaugaaccg
cuuagggauauguggcgucaaaacuugugggcucauucucgauacgugaa
aaggguguugguggauauccaccggccccgaaaauggaugacgcuuaagc
cccaugugcgugauugcccauuauuccuuuggugagggcggcuauauggu
gagaaaguguagcccucccgauguagacguggcgugggggugaggacgaa
gccgauggcgcgagccucggauggacccgccucuagugcagaucuugguu
ggcguagcaaagaucuaacggaauauuuuuaaaugcaacguuggauacug
gagcggggaaggauuucgugccaacggcacucguacacgaguuguucggu
cacugagcacaacguuacaccguuuuguuaggaaagugaaggugcucuga
aaaggggcaacagagaaccugggaugauauuccaaaaagaauugcaugug
ggac
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>........<<........>>......>>>.<<.......((.....>>)
)......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<...
.....>>>>>>>......<<<<<........>>>>>..>>>.........
...........................<<....>>...............
.<<<<....>>>>..................................<<<
..<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<
<<<<.......>>>>>.>>>.....>>>>>>....>>>>>>..>>>....
..........<<<<....<<<<..<<.<.<..<....>..>>.>>..>>>
>.>>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<.
.......>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<.....
....>>>.....>>>...<<....>>..<<<<<...>>>>>...<<.<<.
.<<<<....>>>>...>>.>>..<<<<<<<.....>>>>>>.>.....>>
>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<
<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>
.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>
.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.......<<...
<<<<<<....<<<....<<<..<.<<<..>>>.>..>>>..>.>>....>
>>>>>...<..<....<<.<......>>>....>..>......>>..>>>
>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>
>..<<<<<<<...<<<(((......<<.<<<<........<.........
..<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>
>>>>...........>>>...>>>>>>><<<<.<<<<<...........>
>>>>........>>>>>>>>>....>>>>>..<.<<<<<<<<........
<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>.
.............<<<<<<<..................>>>>>>>.....
...............<<<<<....<<.....>>..>>>>>.....<....
......<<.<<<<<......>>>>...............<<<...>>>..
....>.>>..........<<<<.........>>....>>.>.........
....
Receptor-Ligand Complex Structure
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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		K3 R4 G9 G12 R13 R17
Binding residue
(residue number reindexed from 1)		K2 R3 G8 G11 R12 R16
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ38AW9

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