Structure of PDB 8ova Chain Bm Binding Site BS01

Receptor Information
>8ova Chain Bm (length=98) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APVPRTGIIAGFNKGYKTTRRARRPSSNDRYALPHKKLRAVKAIISDLVG
FSPMERRVQELLRVGKDKRALKFCKKRLGSIKAAKKRRAKVEEALRQQ
Ligand information
>8ova Chain BA (length=1604) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauuacaacccuucaugugaguauugagccaaagaaggugucagcc
cauuacagccacggagccuacgcgccuccucaagagaguagcacuguuug
ggaaugcagugucaagccggcagguauuugucugccaagguuaaauauag
aguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagu
acuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugg
aaguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuuc
cggggcuaacauccggugggucacugugcggguuucgaggucauggggug
cgugagugggcggaauaaagggucgguguguuguguucuuccuccuuccc
uguccgugcgucucgacgcuggcgauggaaauggggugcccccacccguc
uugaaacacggaccaaggagucaaacagacgcgcaagggaggaguauugu
gacaacucuuuucucguacugaaagggaggugugauacacccguggcgug
cgcaauuuuuugcccaacaccgaccggcccuccgugggcugcgcgcgagu
gugccuguuuggacccgaaagguggugaacuaugccugaacaaggugaag
cccggggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgc
ucguacgauuuggguaucggagcgaaagacucaucgaaccaccuaguagc
ugguucacgucgaaguuucccucaggauagcuggugcuugucaagaagua
uugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaug
ugcaaacaacccagccuuaguuauuuuaacaaggcuuuaagaauugaggc
accaagugggccuucuucgguaagcggagcaggcgaugcggaaugaaccg
cuuagggauauguggcgucaaaacuugugggcucauucucgauacgugaa
aaggguguugguggauauccaccggccccgaaaauggaugacgcuuaagc
cccaugugcgugauugcccauuauuccuuuggugagggcggcuauauggu
gagaaaguguagcccucccgauguagacguggcgugggggugaggacgaa
gccgauggcgcgagccucggauggacccgccucuagugcagaucuugguu
ggcguagcaaagaucuaacggaauauuuuuaaaugcaacguuggauacug
gagcggggaaggauuucgugccaacggcacucguacacgaguuguucggu
cacugagcacaacguuacaccguuuuguuaggaaagugaaggugcucuga
aaaggggcaacagagaaccugggaugauauuccaaaaagaauugcaugug
ggac
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>........<<........>>......>>>.<<.......((.....>>)
)......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<...
.....>>>>>>>......<<<<<........>>>>>..>>>.........
...........................<<....>>...............
.<<<<....>>>>..................................<<<
..<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<
<<<<.......>>>>>.>>>.....>>>>>>....>>>>>>..>>>....
..........<<<<....<<<<..<<.<.<..<....>..>>.>>..>>>
>.>>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<.
.......>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<.....
....>>>.....>>>...<<....>>..<<<<<...>>>>>...<<.<<.
.<<<<....>>>>...>>.>>..<<<<<<<.....>>>>>>.>.....>>
>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<
<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>
.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>
.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.......<<...
<<<<<<....<<<....<<<..<.<<<..>>>.>..>>>..>.>>....>
>>>>>...<..<....<<.<......>>>....>..>......>>..>>>
>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>
>..<<<<<<<...<<<(((......<<.<<<<........<.........
..<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>
>>>>...........>>>...>>>>>>><<<<.<<<<<...........>
>>>>........>>>>>>>>>....>>>>>..<.<<<<<<<<........
<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>.
.............<<<<<<<..................>>>>>>>.....
...............<<<<<....<<.....>>..>>>>>.....<....
......<<.<<<<<......>>>>...............<<<...>>>..
....>.>>..........<<<<.........>>....>>.>.........
....
Receptor-Ligand Complex Structure
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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		G22 Y23 N35 R37 Y38 A39 P41 H42 K44 R46 K49 R84 L85 R94 K97
Binding residue
(residue number reindexed from 1)		G15 Y16 N28 R30 Y31 A32 P34 H35 K37 R39 K42 R77 L78 R87 K90
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ38CY6

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