Structure of PDB 8ova Chain Bj Binding Site BS01

Receptor Information
>8ova Chain Bj (length=116) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CPRVQYRRRMHYATRGNRMRLVRTPGNRLVMQKRGKRSQGPHTPWVLGHK
RLAGTKALRHTKARLAPRHQKTTSRPYGGVLSHEQVRDRIVRAFLIEEQR
IVKRALKAHAKVQKEK
Ligand information
>8ova Chain BA (length=1604) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauuacaacccuucaugugaguauugagccaaagaaggugucagcc
cauuacagccacggagccuacgcgccuccucaagagaguagcacuguuug
ggaaugcagugucaagccggcagguauuugucugccaagguuaaauauag
aguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagu
acuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugg
aaguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuuc
cggggcuaacauccggugggucacugugcggguuucgaggucauggggug
cgugagugggcggaauaaagggucgguguguuguguucuuccuccuuccc
uguccgugcgucucgacgcuggcgauggaaauggggugcccccacccguc
uugaaacacggaccaaggagucaaacagacgcgcaagggaggaguauugu
gacaacucuuuucucguacugaaagggaggugugauacacccguggcgug
cgcaauuuuuugcccaacaccgaccggcccuccgugggcugcgcgcgagu
gugccuguuuggacccgaaagguggugaacuaugccugaacaaggugaag
cccggggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgc
ucguacgauuuggguaucggagcgaaagacucaucgaaccaccuaguagc
ugguucacgucgaaguuucccucaggauagcuggugcuugucaagaagua
uugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaug
ugcaaacaacccagccuuaguuauuuuaacaaggcuuuaagaauugaggc
accaagugggccuucuucgguaagcggagcaggcgaugcggaaugaaccg
cuuagggauauguggcgucaaaacuugugggcucauucucgauacgugaa
aaggguguugguggauauccaccggccccgaaaauggaugacgcuuaagc
cccaugugcgugauugcccauuauuccuuuggugagggcggcuauauggu
gagaaaguguagcccucccgauguagacguggcgugggggugaggacgaa
gccgauggcgcgagccucggauggacccgccucuagugcagaucuugguu
ggcguagcaaagaucuaacggaauauuuuuaaaugcaacguuggauacug
gagcggggaaggauuucgugccaacggcacucguacacgaguuguucggu
cacugagcacaacguuacaccguuuuguuaggaaagugaaggugcucuga
aaaggggcaacagagaaccugggaugauauuccaaaaagaauugcaugug
ggac
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>........<<........>>......>>>.<<.......((.....>>)
)......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<...
.....>>>>>>>......<<<<<........>>>>>..>>>.........
...........................<<....>>...............
.<<<<....>>>>..................................<<<
..<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<
<<<<.......>>>>>.>>>.....>>>>>>....>>>>>>..>>>....
..........<<<<....<<<<..<<.<.<..<....>..>>.>>..>>>
>.>>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<.
.......>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<.....
....>>>.....>>>...<<....>>..<<<<<...>>>>>...<<.<<.
.<<<<....>>>>...>>.>>..<<<<<<<.....>>>>>>.>.....>>
>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<
<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>
.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>
.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.......<<...
<<<<<<....<<<....<<<..<.<<<..>>>.>..>>>..>.>>....>
>>>>>...<..<....<<.<......>>>....>..>......>>..>>>
>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>
>..<<<<<<<...<<<(((......<<.<<<<........<.........
..<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>
>>>>...........>>>...>>>>>>><<<<.<<<<<...........>
>>>>........>>>>>>>>>....>>>>>..<.<<<<<<<<........
<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>.
.............<<<<<<<..................>>>>>>>.....
...............<<<<<....<<.....>>..>>>>>.....<....
......<<.<<<<<......>>>>...............<<<...>>>..
....>.>>..........<<<<.........>>....>>.>.........
....
Receptor-Ligand Complex Structure
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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		R5 Q7 R9 R11 H13 Y14 T16 R17 T26 G28 R30 Q34 K38 R61 H62
Binding residue
(residue number reindexed from 1)		R3 Q5 R7 R9 H11 Y12 T14 R15 T24 G26 R28 Q32 K36 R59 H60
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ383V6

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