Structure of PDB 8ova Chain Bg Binding Site BS01

Receptor Information

>8ova Chain Bg (length=92) Species: 5702 (Trypanosoma brucei brucei)

DTINTKIQLVMKSGKYVLGTQQSLKTLRQGRSKLVVISANCPPIRKAEIE
YYCTLSKTPIHHYSGNNLDLGTACGRHFRACVLSITDVGDSD

Ligand information

>8ova Chain BE (length=188)

cuguggaaaugcgaaacacuugccaggugacccauccauccucccacggu
gagcuuucuuuucaccauaauccacuugggccucucgacuucucgcguua
cucggagcgggggcucaagauugaaaaaugcagcucacccuacguacugu
ugugaguucggcgcauuaaagcaaaaaccugggguguu

..<<<....>>>.....<<<..<<<<<<.......<<...<<<<...<<<
<<<.......>>>>>><...<<.<<<<<<<<<<<<........<<.....
..>>....>>>>>>>>>>>.>.>>....><<<<...<<.....>>.>>>>
.>.>>>...>>...............>>>>>>>>>...

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
• Resolution: 2.47 Å
• Binding residue (original residue number in PDB): G37 T38 Q39 Q40 R63 R94 F96 R97 C99
• Binding residue (residue number reindexed from 1): G19 T20 Q21 Q22 R45 R76 F78 R79 C81

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ova, PDBe:8ova, PDBj:8ova
• PDBsum: 8ova
• PubMed: 37985661
• UniProt: P49153|RL30_TRYBB Large ribosomal subunit protein eL30 (Gene Name=RPL30)