Structure of PDB 8evs Chain Bg Binding Site BS01

Receptor Information
>8evs Chain Bg (length=312) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKF
GVPVRSFKGHSHIVQDCTLTADGAYALSASWDKTLRLWDVATGETYQRFV
GHKSDVMSVDIDKKASMIISGSRDKTIKVWTIKGQCLATLLGHNDWVSQV
RVVPNEKADDDSVTIISAGNDKMVKAWNLNQFQIEADFIGHNSNINTLTA
SPDGTLIASAGKDGEIMLWNLAAKKAMYTLSAQDEVFSLAFSPNRYWLAA
ATATGIKVFSLDPQYLVDDLRPEFAGYSKAAEPHAVSLAWSADGQTLFAG
YTDNVIRVWQVM
Ligand information
Ligand IDC
InChIInChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyIERHLVCPSMICTF-XVFCMESISA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1=NC(=O)N(C=C1)[CH]2O[CH](CO[P](O)(O)=O)[CH](O)[CH]2O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O
CACTVS 3.341NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H]2O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
ACDLabs 10.04O=C1N=C(N)C=CN1C2OC(C(O)C2O)COP(=O)(O)O
FormulaC9 H14 N3 O8 P
NameCYTIDINE-5'-MONOPHOSPHATE
ChEMBLCHEMBL307679
DrugBankDB03403
ZINCZINC000003861744
PDB chain8evs Chain BR Residue 219 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8evs Regulation of translation by ribosomal RNA pseudouridylation.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		Y281 A284
Binding residue
(residue number reindexed from 1)		Y277 A280
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001965 G-protein alpha-subunit binding
GO:0005080 protein kinase C binding
GO:0005092 GDP-dissociation inhibitor activity
GO:0043022 ribosome binding
GO:0045182 translation regulator activity
Biological Process
GO:0002181 cytoplasmic translation
GO:0006521 regulation of cellular amino acid metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0010629 negative regulation of gene expression
GO:0017148 negative regulation of translation
GO:0061157 mRNA destabilization
GO:0070651 nonfunctional rRNA decay
GO:0072344 rescue of stalled ribosome
GO:1902660 negative regulation of glucose mediated signaling pathway
GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process
GO:1990145 maintenance of translational fidelity
GO:2001125 negative regulation of translational frameshifting
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8evs, PDBe:8evs, PDBj:8evs
PDBsum8evs
PubMed37595043
UniProtP38011|GBLP_YEAST Small ribosomal subunit protein RACK1 (Gene Name=ASC1)

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