Structure of PDB 8ove Chain Bd Binding Site BS01

Receptor Information
>8ove Chain Bd (length=69) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKSKNHTNHNQSRKNHRNGIKPPLPLYMYNSKRGGWLPALVNTRRVRKNN
QKAALKARRERLAAHQAAQ
Ligand information
>8ove Chain BA (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauacaacccuucaugugaguauugagccaaagaaggugucagccc
auuacagccacggagccuacgcgccuccucaagagaguagcacuguuugg
gaaugcagugucaagccggcagguauuugucugccaagguuaaauauaga
guaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagua
cuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugga
aguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuucc
ggggcuaacauccgguggguacugugcggguuucgaggucauggggugcg
ugagugggcggaauaaagggucggugguuguguucuuccuccuucccugu
ccgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggaguauugugac
aacuuuucucguacugaaagggaggugugauacacccguggcgugcgcaa
uuuguguuuuugcccaacaccgaccggcgugggcugcgcgcgagugugcc
uguuuggacccgaaagguggugaacuaugccugaacaaggugaagcccgg
ggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgcucgua
cgauuuggguaucggagcgaaagacucaucgaaccaccuaguagcugguu
cacgucgaaguuucccucaggauagcuggugcuuguuaagaaguauugug
cgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaugugcaa
acaacccagccuuaguuauaacaaggcuggguaauugaggcaccaagugg
gccuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggau
auguggcgucaaaacuugugggcucauucucgauacgugaaaaggguguu
gguggauauccaccggccccgaaaauggaugacgcuuaagccccaugugc
gugauugcccauuauuccuuuggugagggcggcuauaugugagaaagugu
agcccucccgauguagacguggcgugggggugaggacgaagccgauggcg
cgagccucggauggacccgccucuagugcagaucuugguuggcguagcaa
agaucuaacggaauauuuuuaaaugcaacguuggauacuggagcggggaa
ggauuucgugccaacggcacucguacacgaguuguucggucacugagcac
aacguuacaccguuuuguuaggaaagaaaaggggcaacagagaaccuggg
augauauuccaaaaagaauugcauguggg
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>.......<<........>>......>>>.<<.......((.....>>))
......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<....
....>>>>>>>......<<<<<........>>>>>..>>>..........
..........................<<....>>................
<<<<....>>>>..................................<<<.
.<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<<
<<<.......>>>>>.>>>....>>>>>>....>>>>>>..>>>......
........<<<<....<<<<..<<.<<..<....>..>>.>>..>>>>.>
>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<........
.>>>...>>>...<<....>>..<<<<<...>>>>>......<...<.<.
......>.>....>.....<<<.<<......>>.>>.>.....>>>>>.>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<
<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
.<<<<<....<.<<<....>>>.><<<<<<<<<.......<<.<.<<<<<
<....<<<....<<<....<<<..>>>....>>>..>.>>....>>>>>>
...<<<<<<<<<<.<<<..>>>>>>>>>>>>>.>>>..>>>>>>>.>>..
<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<
<...<<<(((......<<.<<<<........<...........<<<.<<<
<<<<<<..>>>>>>>>>>>>..........))).>....>>>>>>.....
......>>>...>>>>>>><<<<.<<<<<..........>>>>>......
..>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<.
...>>>.>>>.>.....>>>>>>>>..>.....>>>>>>...........
...<<<<<<<..................>>>>>>>...............
.....<<<<<....<<.....>>..>>>>>.....<..........<<.<
<<<<......>>>>.................>.>>..........<<<<.
........>>....>>.>...........
Receptor-Ligand Complex Structure
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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K5 N6 H7 T8 N9 H10 N11 Q12 S13 R14 K15 H17 R18 N19 P26 Y28 M29 Y30 S32 N43 T44 R45 R46 V47 K49 N50 N51 Q52 R60
Binding residue
(residue number reindexed from 1)		K4 N5 H6 T7 N8 H9 N10 Q11 S12 R13 K14 H16 R17 N18 P25 Y27 M28 Y29 S31 N42 T43 R44 R45 V46 K48 N49 N50 Q51 R59
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ383S6

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