Structure of PDB 8ova Chain Bc Binding Site BS01

Receptor Information
>8ova Chain Bc (length=144) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THSTDLQWLLVRQNSKFLQKRNGIRLSSDPFNNNANWTKRQSGFLNTKAA
VIKTKGDRILLTTKSGDTNNKPKLMYKKTVMEPGVKSSVVKRAVADIRPD
LAKMAYRRARKMACTITRMKKVCAARKERSSKMHFHRKTVRPKR
Ligand information
>8ova Chain BA (length=1604) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauuacaacccuucaugugaguauugagccaaagaaggugucagcc
cauuacagccacggagccuacgcgccuccucaagagaguagcacuguuug
ggaaugcagugucaagccggcagguauuugucugccaagguuaaauauag
aguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagu
acuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugg
aaguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuuc
cggggcuaacauccggugggucacugugcggguuucgaggucauggggug
cgugagugggcggaauaaagggucgguguguuguguucuuccuccuuccc
uguccgugcgucucgacgcuggcgauggaaauggggugcccccacccguc
uugaaacacggaccaaggagucaaacagacgcgcaagggaggaguauugu
gacaacucuuuucucguacugaaagggaggugugauacacccguggcgug
cgcaauuuuuugcccaacaccgaccggcccuccgugggcugcgcgcgagu
gugccuguuuggacccgaaagguggugaacuaugccugaacaaggugaag
cccggggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgc
ucguacgauuuggguaucggagcgaaagacucaucgaaccaccuaguagc
ugguucacgucgaaguuucccucaggauagcuggugcuugucaagaagua
uugugcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaug
ugcaaacaacccagccuuaguuauuuuaacaaggcuuuaagaauugaggc
accaagugggccuucuucgguaagcggagcaggcgaugcggaaugaaccg
cuuagggauauguggcgucaaaacuugugggcucauucucgauacgugaa
aaggguguugguggauauccaccggccccgaaaauggaugacgcuuaagc
cccaugugcgugauugcccauuauuccuuuggugagggcggcuauauggu
gagaaaguguagcccucccgauguagacguggcgugggggugaggacgaa
gccgauggcgcgagccucggauggacccgccucuagugcagaucuugguu
ggcguagcaaagaucuaacggaauauuuuuaaaugcaacguuggauacug
gagcggggaaggauuucgugccaacggcacucguacacgaguuguucggu
cacugagcacaacguuacaccguuuuguuaggaaagugaaggugcucuga
aaaggggcaacagagaaccugggaugauauuccaaaaagaauugcaugug
ggac
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>........<<........>>......>>>.<<.......((.....>>)
)......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<...
.....>>>>>>>......<<<<<........>>>>>..>>>.........
...........................<<....>>...............
.<<<<....>>>>..................................<<<
..<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<
<<<<.......>>>>>.>>>.....>>>>>>....>>>>>>..>>>....
..........<<<<....<<<<..<<.<.<..<....>..>>.>>..>>>
>.>>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<.
.......>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<.....
....>>>.....>>>...<<....>>..<<<<<...>>>>>...<<.<<.
.<<<<....>>>>...>>.>>..<<<<<<<.....>>>>>>.>.....>>
>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<
<<.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>
.>>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>
.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.......<<...
<<<<<<....<<<....<<<..<.<<<..>>>.>..>>>..>.>>....>
>>>>>...<..<....<<.<......>>>....>..>......>>..>>>
>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>
>..<<<<<<<...<<<(((......<<.<<<<........<.........
..<<<.<<<<<<<<<..>>>>>>>>>>>>..........))).>....>>
>>>>...........>>>...>>>>>>><<<<.<<<<<...........>
>>>>........>>>>>>>>>....>>>>>..<.<<<<<<<<........
<<<<..<<<....>>>.>>>.>.....>>>>>>>>..>.....>>>>>>.
.............<<<<<<<..................>>>>>>>.....
...............<<<<<....<<.....>>..>>>>>.....<....
......<<.<<<<<......>>>>...............<<<...>>>..
....>.>>..........<<<<.........>>....>>.>.........
....
Receptor-Ligand Complex Structure
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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)
Q14 K21 N23 G24 I25 R26 P31 F32 N37 T39 R41 K79 G85 K87 S88 S89 P100 D101 K104 M105 Y107 R108 R111 C115 T118 K122 R127 K128 R130 S131 M134 H135 F136 H137 R138 T140 R142 R145
Binding residue
(residue number reindexed from 1)
Q13 K20 N22 G23 I24 R25 P30 F31 N36 T38 R40 K78 G84 K86 S87 S88 P99 D100 K103 M104 Y106 R107 R110 C114 T117 K121 R126 K127 R129 S130 M133 H134 F135 H136 R137 T139 R141 R144
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ385E9

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