Structure of PDB 6th6 Chain Ba Binding Site BS01

Receptor Information

>6th6 Chain Ba (length=154) Species: 69014 (Thermococcus kodakarensis KOD1)

AKLALIRLRSGIRARGEVRDTLAMLRLHRINHLVIVDDTPSYRGMIQKVK
DYITWGEIDKETLAKLLRKRGRLIGNKPITDEYVKEKLGMTIEEFAEKVV
NGEMKLRDLPNIKPVFRLHPPRGGLKGSKKRSFKEGGALGYRGEKINELI
ERML

Ligand information

>6th6 Chain BA (length=2934)

cccgguggcaacuaagccgccugguggauggcucggcucggggcgccgac
gaagggcguggcaagcugcgauaagccccggcgaggcgcaggcagccguc
gaaccggggaugcccgaaugggaccucccgcggcuugccgcacucccagu
cgggagggggaacgcggggaauugaaacaucuuaguacccgcaggaaaag
aaagcaaaagcgaugccguuaguaggggcgaccgaaagcggcacagggca
aacugaaccccgggccgaaagguucgggggaugugguguuguagggcccg
cggaggagcccugggggcgaagccgaaguccgcuggaacgcggcgccgga
gagggugaaagccccguaggcguaagcccccgagcuccugcggugucccu
gaguaccgucggucggauauccggcgggaagcugggaggcaucggcuccc
aacccuaaauacgucccgagaccgauagcgaacuaguaccgugagggaaa
gcugaaaagcaccccgggaggggggugaaaagagccugaaaccaggcggc
gauaggagggugcggcccgaaaggguugacccuccccgaaggaaacacgg
gcgaccguggaguacgaggggaggugaccgggguugcaccguccgucuug
gaucacggggcagggaguucacccgagcggcgagguuaagggggucaacc
ccgaagccgcagggaaaccgacagguccgcagcccguagggcgagggacg
gggugugaaagcgcccggagucgcucgggugagacccgaagccggucgau
cuagcccggggcagggugaagucccucaacagagggauggaggcccgcua
ggggugcugacgcgcaauucgcucccgugaccccgggcuaggggugaaag
gccaaucgaggccggcgauagcugguucccgccgaauuaucccccaggau
agcccggccggagguaggcagugggguagagcacugauuggggguuuagg
gggcgaaagccuccggcucccugucaaacuccgaacccacugccgccgua
gauggccggaguaggggggcgguguaagccgucacccgagaggggaacaa
cccagaccgggguuaaggccccaaagugccggcuaaguguuacuccaaag
ggugucccuggccuuagacagcggcccgucgaggucaggggccccgaaaa
uggacggggcuuaagccggccgccgagaccccggcgcacggaccgauugg
uccgugaucggguaggcgggcgugccgauggggcggaagccgggccguga
gguccgguggacccgucgguauugcggauccugccgggaguagcagcaua
gccgggugagaaucccggccgccguaggggccaggguuccacggcaaugu
ucgucagccguggguuagucgguccuaacccgacccguaacucggcgucg
gggaaagggaaacggguuuauauucccguaccgcggugguaggugcggca
acgcaagcccgaggggugacgccucgggguaggcggaccgguccacaagg
ccggcuaagcguauaagcccggggagugccguaauggcgagaaccgggug
aaagcgcgaauggccucccguaagggggguuccgccgaucccuggggccc
gugaaaagccccucgggaacgauccaccgcgaccguaccgagaaccgaca
cuggugccccugggugagaagccuaaggcgugucgggggaaacccagccg
agggaacucggcaaauuggccccguaacuucgggagaaggggugccugcg
gguguguaacccgcaggucgcagugacuaggggggcccgacuguuuagua
aaaacacaggucccagcuagcccgaaaggguuuguacuggggccgacgcc
ugcccagugccgguaugugaagcccggguacaaccgggugaagcaccggu
aaacggcggggguaacuauaacccucuuaagguagcgaaauuccuugucg
guuaaaugccgaccugcaugaauggcguaacgagguccccacuguccccg
gcuggggcccggcgaaaccucugccaggcgcauaugccugggaccuccgg
ugggaagcgaagaccccauggagcuuuacugcagccugccguugccguac
ggcggggggugcgcagcguaggcgggaggcgucgaagcccgcccuccggg
gcggguggagccgcccaugagacaccgcccacccucugccguacggcuaa
cccgcggaagcggggacagcgguaggugggcaguuuggcuggggcggcac
acccucgaaaagguaucgagggugcccuaaggucggcucaggcgggucag
gaauccgccguagagugcaagggcaaaagccggccugacuggacccguaa
cagaggcggguccagccgcgaaagcguggccuagcgaaccccugugccuc
cccggugggggccagggaugacagaaaagcuacccuggggauaacagagu
cgucucgggcgagagcccauaucgaccccgaggcuugcuaccucgcuguc
ggcucuucccauccuggcccugcagcaggggccaaggguggggguguuca
cccauuaaaggggaacgugagcuggguuuagaccgucgugagacaggucg
gaugcuaucuaccggagguguuggccgccugaggggaaggcucccccagu
acgagaggaacagggagccgcggccucuggucuaccgguuguccuacagg
gcauagccgggcagcuacgccgcagccgauaaggccugaaagcaucuaag
gccgaagcggcccccgaaaacaggcggccaccgagggcccgggaagaaga
cccgguugauggggcggggauguaagcgggaagggaaaccgacccguuca
gucugccgcucccaacagcccgagugcuaccggg

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>>>>....<<<<.<..<<<<<<.....<<<<...>>>>.....>>>>>>.
..>>>>>.....<<<<<<......>>>>>>>>>>>>...>>>>>>>>>..
.......>>>>>>>>>>......>>>>>>>>>>>>..>>.....<<....
..>>...>>>.<<<<.....>>>>..>>>>...<<<<.....<<<<<<<<
.<<.........<.....<<<<<...............>>>>><<<<<<<
<<<.....>>>>>>>>>>............<<<<<<<<<..<<<......
...>>>..<<<<<<<....<<<<....>>>>......>>>>>>>.<<<<<
.<<<..<<<<<<<..<<<...<<<<<<......>>>>>>...>>>>>>>>
..>>>>><<<<<<.......>>>>>>........<...........<<<<
<<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>
>>>>>>.>>>>>>....>>....<<<<<........>>>>>..<<<<<<<
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<<<<..<<<<..........<<<<<..<<<......<<<<<<.<<...>>
>>>>>>...>>>............>>>>>.>.>>>.>>>>>>>>>>>...
<<<<<....>>>>>....>>>>>>>>>..>>>>>.....<.....>....
<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<....
...>>>>>>.....<<...(((>>....>>>>>>>...<<<<<<<<<<..
.....>>>>>>>>>>.<<<....>>>.>>))).......<<<<<.<<<<<
.>>>>>>>>>>>>>>>>..........>>>>..]]>>>>.......<<<<
.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<
<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>..<<<.......
>>>......>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>.
...]]..>>>>>>>>>>>....<<<<<<<<..<<<<..<<<<<<<.....
............>>>>>>><<<<<...<<<<...<<<<<<<<<<}...>>
>>>..>>>>>...>>>>.>>>>>.<<<<.<..<<<<<...........>>
>>>...>>>>>>>>>>......>>>>>>>.....<<<<<<<<<.......
>>>>>....<<<<<<<<<<<<....<<<<<..<<....>>..>>>>>...
>>>>.>>>>>.>>>...>>>>...>>>>>>>>.>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6th6 Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
• Resolution: 2.55 Å
• Binding residue (original residue number in PDB): S11 I13 R14 A15 R20 D21 M25 R27 H29 R30 I31 S42 Y43 G45 M46 K49 R71 G76 K114 R118 L119 H120 P121 K130 K131
• Binding residue (residue number reindexed from 1): S10 I12 R13 A14 R19 D20 M24 R26 H28 R29 I30 S41 Y42 G44 M45 K48 R70 G75 K113 R117 L118 H119 P120 K129 K130

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6th6, PDBe:6th6, PDBj:6th6
• PDBsum: 6th6
• PubMed: 32555463
• UniProt: Q5JJG9|RL30_THEKO Large ribosomal subunit protein uL30 (Gene Name=rpl30)