Structure of PDB 8ove Chain BZ Binding Site BS01

Receptor Information
>8ove Chain BZ (length=120) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIKCRNRRKARRAHFQAPSHVRRILMSAPLSKELRAKYNVRSMPVRKDDE
VRVKRGKFKGREGRVTACYRLKWVIHIDKVSCEKANGTTVPVGVHTSNVE
ITKLKLNTRRKAILERKDRS
Ligand information
>8ove Chain BA (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauacaacccuucaugugaguauugagccaaagaaggugucagccc
auuacagccacggagccuacgcgccuccucaagagaguagcacuguuugg
gaaugcagugucaagccggcagguauuugucugccaagguuaaauauaga
guaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagua
cuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugga
aguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuucc
ggggcuaacauccgguggguacugugcggguuucgaggucauggggugcg
ugagugggcggaauaaagggucggugguuguguucuuccuccuucccugu
ccgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggaguauugugac
aacuuuucucguacugaaagggaggugugauacacccguggcgugcgcaa
uuuguguuuuugcccaacaccgaccggcgugggcugcgcgcgagugugcc
uguuuggacccgaaagguggugaacuaugccugaacaaggugaagcccgg
ggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgcucgua
cgauuuggguaucggagcgaaagacucaucgaaccaccuaguagcugguu
cacgucgaaguuucccucaggauagcuggugcuuguuaagaaguauugug
cgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaugugcaa
acaacccagccuuaguuauaacaaggcuggguaauugaggcaccaagugg
gccuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggau
auguggcgucaaaacuugugggcucauucucgauacgugaaaaggguguu
gguggauauccaccggccccgaaaauggaugacgcuuaagccccaugugc
gugauugcccauuauuccuuuggugagggcggcuauaugugagaaagugu
agcccucccgauguagacguggcgugggggugaggacgaagccgauggcg
cgagccucggauggacccgccucuagugcagaucuugguuggcguagcaa
agaucuaacggaauauuuuuaaaugcaacguuggauacuggagcggggaa
ggauuucgugccaacggcacucguacacgaguuguucggucacugagcac
aacguuacaccguuuuguuaggaaagaaaaggggcaacagagaaccuggg
augauauuccaaaaagaauugcauguggg
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>.......<<........>>......>>>.<<.......((.....>>))
......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<....
....>>>>>>>......<<<<<........>>>>>..>>>..........
..........................<<....>>................
<<<<....>>>>..................................<<<.
.<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<<
<<<.......>>>>>.>>>....>>>>>>....>>>>>>..>>>......
........<<<<....<<<<..<<.<<..<....>..>>.>>..>>>>.>
>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<........
.>>>...>>>...<<....>>..<<<<<...>>>>>......<...<.<.
......>.>....>.....<<<.<<......>>.>>.>.....>>>>>.>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<
<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
.<<<<<....<.<<<....>>>.><<<<<<<<<.......<<.<.<<<<<
<....<<<....<<<....<<<..>>>....>>>..>.>>....>>>>>>
...<<<<<<<<<<.<<<..>>>>>>>>>>>>>.>>>..>>>>>>>.>>..
<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<
<...<<<(((......<<.<<<<........<...........<<<.<<<
<<<<<<..>>>>>>>>>>>>..........))).>....>>>>>>.....
......>>>...>>>>>>><<<<.<<<<<..........>>>>>......
..>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<.
...>>>.>>>.>.....>>>>>>>>..>.....>>>>>>...........
...<<<<<<<..................>>>>>>>...............
.....<<<<<....<<.....>>..>>>>>.....<..........<<.<
<<<<......>>>>.................>.>>..........<<<<.
........>>....>>.>...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		G3 K5 C6 R7 R9 R13 L27 S29 P31 R43 S44 R57 G58 K59 K86 A87 N88 H97 S99 R118 R121
Binding residue
(residue number reindexed from 1)		G1 K3 C4 R5 R7 R11 L25 S27 P29 R41 S42 R55 G56 K57 K84 A85 N86 H95 S97 R116 R119
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ38D25

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