Structure of PDB 4v5h Chain BY Binding Site BS01

Receptor Information

>4v5h Chain BY (length=79) Species: 562 (Escherichia coli)

GGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRD
HTLFAKADGKVKFEVKGPKNRKFISIEAE

Ligand information

>4v5h Chain BA (length=115)

gcugcggccguagcgcgguggucccaccugaccccaugccgaacucagaa
gugaaacgccguagcgccgaugguaguguggggucuccccaugcgagagu
agggaacugccaggc

<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>>..
>>>...>>>>>>.>>.<<.....<.<<<<<<<<...>>>>>>>>...>..
.>>...>>>>.>>.>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v5h Structural insight into nascent polypeptide chain-mediated translational stalling.
• Resolution: 5.8 Å
• Binding residue (original residue number in PDB): E69 G72 P73 K74
• Binding residue (residue number reindexed from 1): E64 G67 P68 K69

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0019843 rRNA binding
• GO:0043022 ribosome binding

Biological Process

• GO:0000027 ribosomal large subunit assembly
• GO:0001558 regulation of cell growth
• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042256 cytosolic ribosome assembly
• GO:0090070 positive regulation of ribosome biogenesis
• GO:1902626 assembly of large subunit precursor of preribosome

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v5h, PDBe:4v5h, PDBj:4v5h
• PDBsum: 4v5h
• PubMed: 19933110
• UniProt: P0A7L8|RL27_ECOLI Large ribosomal subunit protein bL27 (Gene Name=rpmA)