Structure of PDB 5aj0 Chain BU Binding Site BS01

Receptor Information
>5aj0 Chain BU (length=97) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTP
CGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTI
Ligand information
>5aj0 Chain B1 (length=1708) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgacuuggauaacugugguaauucua
gagcuaauacaugccgacgggcgcugacccccuucgcgggggggaugcgu
gcauuuaucagaucaaaaccaacccgggcuuuggugacucuagauaaccu
cgggccgaucgcacgccccccguggcggcgacgacccauucgaacgucug
cccuaucaacuuucgaugguagucgccgugccuaccauggugaccacggg
ugacggggaaucaggguucgauuccggagagggagccugagaaacggcua
ccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacccgg
ggagguagugacgaaaaauaacaauacaggacucuuucgaggcccuguaa
uuggaaugaguccacuuuaaauccuuuaacgaggauccauuggagggcaa
gucuggugccagcagccgcgguaauuccagcuccaauagcguauauuaaa
guugcugcaguuaaaaagcucguaguuggaucuugggagcggccccuugc
cucucgcccgaagcguuuacuuugaaaaaauuagaguguucaaagcaggc
ccgagccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguu
cuauuuuguugguuuucggaacugaggccaugauuaagagggacggccgg
gggcauucguauugcgccgcuagaggugaaauucuuggaccggcgcaaga
cggaccagagcgaaagcauuugccaagaauguuuucauuaaucaagaacg
aaagucggagguucgaagacgaucagauaccgucguaguuccgaccauaa
acgaugccgaccggcgaugcggcggcguuauucccaugacccgccgggca
gcuuccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaa
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacgggaaaccucacccggcccggacacggac
aggauugacagauugauagcucuuucucgauuccgugggugguggugcau
ggccguucuuaguugguggagcgauuugucugguuaauuccgauaacgaa
cgagacucuggcaugcuaacuaguuacgcgacccccgagcgguaacuucu
uagagggacaaguggcguucagccacccgagauugagcaauaacaggucu
gugaugcccuuagauguccggggcugcacgcgcgcuacacugacuggcuc
agcgugugccuacccuacgccggcaggcgcggguaacccguugaacccca
uucgugauggggaucggggauugcaauuauuccccaugaacgaggaauuc
ccaguaagugcgggucauaagcuugcguugauuaagucccugcccuuugu
acacaccgcccgucgcuacuaccgauuggaugguuuagugaggcccucgg
aucggccccgccguggcggagcgcugagaagacggucgaacuugacuauc
uagaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaag
gaucauua
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[[[....<<.....<<.<<<.....>>>
.>>......>>.........<<<<...<<<<<<....>>>>>>...>>>>
[[..(((((.....<<<<<<<<.<<.>>....<......>..)))))...
...]]...<<<<..<<<......>>>.>>>>.]].]]]...}}....]]]
.<<<....<<<....<<<<<<<.........>>>>>>>>>>......>>>
...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>>>.
>>.<.<<....>>.>...]]]]]].........<<<....<<<<...>>>
>..>>>......}}.......<<<<<<<<<.<<<....>>>..>>>>>.>
>>>......<<..<...........>..>>.........<<<<<((....
..<<<<.....<<..))>>.......>>>>.>>>>>..)))))).]]]..
..........{{.......{{...[[[.......<<<.....>>>....<
.<..<....>>.>....<<<<<.<.......<<...<.......>.<<<<
.......>>>>...>>......>.>>>..>>...........[...((((
((......>>>>>>>>.))))))...]............<<<<<<..<..
.<<<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..
>>.......<<....>>...>>>>..>..>>>.>>>...]]]...}}...
...<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>.....
.....<<<.<<.<<<..<.<<<<<<.<<<........>>>>>>>>>.>..
>>>...<<..}}>>...>>.....>>>.....<<<......<<<<....>
>>>....>>>..]]]]..<<<<<.<<<<<<<..<<..<<<<<..<<<.<<
<<........<<........>>..........<<<<<......<<<<<..
......<<.<<<........>>>.>>......>>>>>...<<.<<<..<<
.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>
>....<<<...<...<<<<..<<<<..<<..<......>..>>>>>>..>
>>>..>.....<<<<<.....>>>>>........>>>....>>>.>>>..
...>>>>>>>.......>>>>>......>>>>.>>>.....<<.<<<...
.....<.......<<<.<<<<....>>>>.>>>....>.........>>>
.>>......<.....<<<<<..........>>>>>.....>.....>>>>
>.....<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>
.>>....<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<..
.<<<<<.<<<<<..>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>
>...>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.
........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5aj0 Structural Snapshots of Actively Translating Human Ribosomes
Resolution3.5 Å
Binding residue
(original residue number in PDB)		R21 V29 E33 K51 G52 V54 R55 M56 P57 T58 K59 R62 T68 P69 C70 G71 E72 S74 K75 T76 R83 H85 K86 R87 L88
Binding residue
(residue number reindexed from 1)		R2 V10 E14 K32 G33 V35 R36 M37 P38 T39 K40 R43 T49 P50 C51 G52 E53 S55 K56 T57 R64 H66 K67 R68 L69
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0097371 MDM2/MDM4 family protein binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5aj0, PDBe:5aj0, PDBj:5aj0
PDBsum5aj0
PubMed25957688
UniProtP60866|RS20_HUMAN Small ribosomal subunit protein uS10 (Gene Name=RPS20)

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